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Vol. 89, No. 1-2, 2000
Issue release date: 2000
Section title: Paper
Cytogenet Cell Genet 89:18–23 (2000)
(DOI:10.1159/000015583)

The small GTPase RAC3 gene is located within chromosome band 17q25.3 outside and telomeric of a region commonly deleted in breast and ovarian tumours

Morris C.M.a · Haataja L.b · McDonald M.a · Gough S.a · Markie D.c · Groffen J.b · Heisterkamp N.b
aCytogenetic and Molecular Oncology Unit, Department of Pathology, Christchurch School of Medicine, Christchurch (New Zealand); bSection of Molecular Carcinogenesis, Division of Hematology-Oncology, Children’s Hospital Los Angeles Research Institute and School of Medicine, University of Southern California, Los Angeles, CA (USA); and cLaboratorio di Genetica Molecolare, Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin (New Zealand)

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 6/26/2000
Issue release date: 2000

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 1

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

Abstract.

The closely related small GTP-binding proteins Rac1, Rac2, and Rac3 are part of a larger Rho subfamily of Ras proteins. Because disruption of Ras signaling pathways is relevant to the pathogenesis of a wide variety of cancers, it is important to clearly define the structural and functional characteristics of the participating proteins and their encoding genes. Rho subfamily members are involved in a range of signal transduction pathways relevant to cell growth, differentiation, motility, and stress, and Rac proteins are now recognised as a necessary component of Ras-mediated cellular transformation. We previously mapped RAC3 to chromosome band 17q23→ q25, a region that contains a number of candidate tumour suppressor genes. Because of its oncogenic potential, we have now further refined the location of this gene. Here we confirm that RAC3 maps to chromosome band 17q25.3 and further show that it maps some distance telomeric of a well-characterised minimal breast and ovarian candidate tumour suppressor gene region, BROV. The genomic structure of RAC3, including exon and intron boundaries, is also presented.   

© 2000 S. Karger AG, Basel


  

Article Information

Supported by the Cancer Society of New Zealand, New Zealand Lottery Health, the Canterbury Medical Research Foundation, the W.H. Travis Trust, and the Breast Cancer Fund of the State of California through the Breast Cancer Research program of the University of California (Grant No. 1RB-0001).

Received: Received 19 July 1999;
revision accepted 11 January 2000.
Number of Print Pages : 6
Number of Figures : 3, Number of Tables : 1, Number of References : 28

  

Publication Details

Cytogenetics and Cell Genetics
Founded 1962 as Cytogenetics by H.P. Klinger

Vol. 89, No. 1-2, Year 2000 (Cover Date: 2000)

Journal Editor: H.P. Klinger, Bronx, N.Y.; M. Schmid, Würzburg
ISSN: 0301–0171 (print), 1422–9816 (Online)

For additional information: http://www.karger.com/journals/ccg


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 6/26/2000
Issue release date: 2000

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 1

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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