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Vol. 89, No. 1-2, 2000
Issue release date: 2000
Section title: Paper
Cytogenet Cell Genet 89:133–136 (2000)
(DOI:10.1159/000015592)

Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAFI48, TAFI63 and TAFI110 subunits of class I general transcription initiation factor SL1

Di Pietro C.a · Rapisarda A.a · Amico V.a · Bonaiuto C.b · Viola A.a · Scalia M.a · Motta S.c · Amato A.d · Engel H.e · Messina A.b · Sichel G.a · Grzeschik K.-H.e · Purrello M.a
aDipartimento di Scienze biomediche, Sezione di Biologia generale, cellulare e di Genetica molecolare; bDipartimento di Scienze biomediche, Sezione di Patologia generale; cDipartimento di Biologia animale, Università di Catania, Catania (Italy); dIstituto di Biologia generale, Università di Messina, Messina (Italy); eMedizinisches Zentrum für Humangenetik, Philipps Universität, Marburg (Germany)

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 6/26/2000
Issue release date: 2000

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

Abstract.

Human SL1 is a general transcription initiation factor (GTF) essential for RNA polymerase I to start rRNA synthesis at class I promoters. It is comprised of the TATA box-binding protein (TBP) and three TBP-associated factors (TAFI48, TAFI63 and TAFI110). We have determined that the human genes TAF1A, TAF1B and TAF1C, encoding these three TAFI polypeptides, are localized at lq42, 2p25 and 16q24, respectively. All three genes are present as single copies in the human genome and map to different chromosomes, as shown by somatic cell hybrid panel and radiation hybrid panel analysis and FISH. Two of these genes, TAF1C and TAF1B, are transcribed into multiple RNAs, as determined through Northern analysis of mRNA from various human organs and cell lines. If translated into different polypeptides, this could result in production of variant isoforms of SL1 with different activation potentials.   


  

Author Contacts

Request reprints from Dr. Michele Purrello, Dipartimento di Scienze biomediche, Sezione di Biologia generale, cellulare e di Genetica molecolare, Via Androne 81, Università di Catania, 95124 Catania (Italy); telephone: 095310503;fax: 095310374; e-mail: purrello@mbox.unict.it
C.D.P. and A.R. contributed equally to the experimental work described in this paper.

  

Article Information

Supported by AIRC (M.P. and A.M.), CNR (M.P.), DFG (K.-H.G.) and the Vigoni program (M.P. and K.-H.G.).

Received: Received 3 December 1999;
manuscript accepted 10 February 2000.
Number of Print Pages : 4
Number of Figures : 1, Number of Tables : 1, Number of References : 15

  

Publication Details

Cytogenetics and Cell Genetics
Founded 1962 as Cytogenetics by H.P. Klinger

Vol. 89, No. 1-2, Year 2000 (Cover Date: 2000)

Journal Editor: H.P. Klinger, Bronx, N.Y.; M. Schmid, Würzburg
ISSN: 0301–0171 (print), 1422–9816 (Online)

For additional information: http://www.karger.com/journals/ccg


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 6/26/2000
Issue release date: 2000

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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