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Table of Contents
Vol. 217, No. 4, 2008
Issue release date: November 2008
Section title: Clinical and Laboratory Studies
Dermatology 2008;217:365–373
(DOI:10.1159/000156599)

Impact of Body Mass Index and Obesity on Clinical Response to Systemic Treatment for Psoriasis

Evidence from the Psocare Project

Naldi L.a · Addis A.d · Chimenti S.f · Giannetti A.c · Picardo M.e · Tomino C.d · Maccarone M.g · Chatenoud L.a, b · Bertuccio P.a, b · Caggese E.a · Cuscito R.d
aGISED Study Centre, Ospedali Riuniti, Bergamo; bUnit of Analytic Epidemiology, Mario Negri Institute for Pharmacological Research, Milan; cDepartment of Dermatology, Modena and Reggio Emilia University, Modena; dItalian Drug Agency (AIFA), eSan Gallicano-IFO Institute, Rome, fDepartment of Dermatology, Tor Vergata University, Rome, and gItalian Psoriatic Patient Association (ADIPSO), Rome, Italy

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Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Studies

Received: November 21, 2007
Accepted: April 15, 2008
Published online: September 23, 2008
Issue release date: November 2008

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 3

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Objective: Our aim was to assess the role of the body mass index (BMI) in the clinical response to systemic treatment for psoriasis. Methods: A nationwide cohort study of patients receiving a new systemic treatment for plaque psoriasis at reference centres in Italy was conducted. Information was gathered through a web-based electronic form. Patients being maintained on the same medication and with data available at 8 and 16 weeks by March 31, 2007, were eligible. The outcome was a reduction in the Psoriasis Area Severity Index (PASI) of at least 75% at follow-up compared to baseline (PASI-75). Results: Out of 8,072 patients enrolled, 2,368 were eligible and analysable at 8 weeks and 2,042 at 16 weeks. PASI-75 was achieved by 819 patients (34.5%) at 8 weeks and 1,034 (50.6%) at 16 weeks. The proportion steadily decreased with increased values of BMI. Compared to normal weight (BMI = 20–24) the adjusted odds ratio for achieving PASI-75 in obese patients was 0.73 (95% CI = 0.58–0.93) at 8 weeks and 0.62 (95% CI = 0.49–0.79) at 16 weeks. The impact of the BMI did not show remarkable variations according to the drug prescribed at entry. Conclusion: The BMI affects the early clinical response to systemic treatment for psoriasis.

© 2008 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Studies

Received: November 21, 2007
Accepted: April 15, 2008
Published online: September 23, 2008
Issue release date: November 2008

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 3

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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