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Vol. 31, No. 5, 2008
Issue release date: December 2008
Section title: Original Paper
Kidney Blood Press Res 2008;31:322–329
(DOI:10.1159/000157177)

Effects of Long-Term Cholecalciferol Supplementation on Mineral Metabolism and Calciotropic Hormones in Chronic Kidney Disease

Okša A. · Spustová V. · Krivošíková Z. · Gazdíková K. · Fedelešová V. · Lajdová I. · Štefíková K. · Bernasovská G. · Žilinská Z. · Dzúrik R.
aDepartment of Clinical and Experimental Pharmacotherapy, Slovak Health University, and bDérer’s University Hospital, Bratislava, Slovakia

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/25/2008
Accepted: 7/17/2008
Published online: 9/19/2008

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 4

ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)

For additional information: http://www.karger.com/KBR

Abstract

Background: Data on the efficacy and safety of long-term vitamin D supplementation in chronic kidney disease (CKD) are scarce. We assessed the effects of the 12-month vitamin D3 treatment on mineral metabolism and calciotropic hormones in patients with CKD stages 2–4. Methods: Eighty-seven patients (mean age 66 years, men/women 33/54) were randomized to cholecalciferol treatment with either 5,000 or 20,000 IU/week. Serum calcium, phosphate, 25(OH)D3, 1,25(OH)2D3, PTH and urinary mineral concentrations were obtained at baseline and after 4, 8 and 12 months. Results: The median serum mineral concentrations were normal and not changed throughout the study. The number of hypercalciuric patients slightly increased with higher dose, but no sustained rise in calciuria was present. Vitamin D insufficiency/deficiency was revealed in 72 (83%) patients at baseline and 37 (43%) at month 12. The 25(OH)D3 levels increased more with higher dose; a rise in 1,25(OH)2D3 was less impressive. The parathyroid hormone (PTH) concentrations were reduced, but the number of subjects with PTH below the lower limit for CKD stage 3 increased equally with both doses. Conclusions: Vitamin D insufficiency/deficiency in CKD significantly improved after the 12-month cholecalciferol treatment, with higher dose being more effective and equally safe. Further studies of vitamin D3 effects on bone metabolism are warranted.


  

Author Contacts

Adrián Okša, MD, PhD
Department of Clinical and Experimental Pharmacotherapy
Slovak Health University, Limbová 12
SK–833 03 Bratislava (Slovak Republic)
Tel. +421 2 5936 9408, Fax +421 2 5936 9466, E-Mail adrian.oksa@szu.sk

  

Article Information

Received: March 25, 2008
Accepted: July 17, 2008
Published online: September 19, 2008
Number of Print Pages : 8
Number of Figures : 2, Number of Tables : 4, Number of References : 26

  

Publication Details

Kidney and Blood Pressure Research

Vol. 31, No. 5, Year 2008 (Cover Date: December 2008)

Journal Editor: Wanner C. (Würzburg)
ISSN: 1420–4096 (Print), eISSN: 1423–0143 (Online)

For additional information: http://www.karger.com/KBR


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/25/2008
Accepted: 7/17/2008
Published online: 9/19/2008

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 4

ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)

For additional information: http://www.karger.com/KBR


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