Nitric oxide (NO) is an important bio-regulatory molecule in the nervous, immune and cardiovascular systems. NO is synthesized from one of the guanidino nitrogens of L-arginine by the enzyme nitric oxide synthase (NOS). To date, several isoforms of NOS have been purified and cloned. These proteins represent a novel family of mammalian enzymes that contain both heme and cytochrome P450 reductase domains. The three prototypical forms of NOS: neuronal, cytokine-inducible and endothelial NOS, are derived from separate genes and are regulated by diverse signaling pathways. The purposes of this review are to highlight recent advances in the enzymology and molecular biology of this important family of proteins and to examine how this information pertains to the regulation of NO production.
Dr. William C. Sessa, Dept. of Pharmacology, Molecular Cardiobiology Division, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06510-0812 (USA)
Received: September 27, 1993
Accepted after revision: November 23, 1993
Published online: September 23, 2008
Number of Print Pages : 13
Journal of Vascular Research (Incorporating 'International Journal of Microcirculation')
Vol. 31, No. 3, Year 1994 (Cover Date: 1994)
Journal Editor: Pohl U. (Munich), Meininger G.A. (Columbia, Mo.)
ISSN: 1018–1172 (Print), eISSN: 1423–0135 (Online)
For additional information: http://www.karger.com/JVR
Copyright / Drug Dosage
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.