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Vol. 31, No. 3, 1994
Issue release date: 1994
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J Vasc Res 1994;31:131–143
(DOI:10.1159/000159039)
Review

The Nitric Oxide Synthase Family of Proteins

Sessa W.C.
Department of Pharmacology and Molecular Cardiobiology Division, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, Conn., USA J Vasc Res 1994;31:131–143 (DOI:10.1159/000159039)

Abstract

Nitric oxide (NO) is an important bio-regulatory molecule in the nervous, immune and cardiovascular systems. NO is synthesized from one of the guanidino nitrogens of L-arginine by the enzyme nitric oxide synthase (NOS). To date, several isoforms of NOS have been purified and cloned. These proteins represent a novel family of mammalian enzymes that contain both heme and cytochrome P450 reductase domains. The three prototypical forms of NOS: neuronal, cytokine-inducible and endothelial NOS, are derived from separate genes and are regulated by diverse signaling pathways. The purposes of this review are to highlight recent advances in the enzymology and molecular biology of this important family of proteins and to examine how this information pertains to the regulation of NO production.

 goto top of outline Author Contacts

Dr. William C. Sessa, Dept. of Pharmacology, Molecular Cardiobiology Division, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06510-0812 (USA)


 goto top of outline Article Information

Received: September 27, 1993
Accepted after revision: November 23, 1993
Published online: September 23, 2008
Number of Print Pages : 13


 goto top of outline Publication Details

Journal of Vascular Research (Incorporating 'International Journal of Microcirculation')

Vol. 31, No. 3, Year 1994 (Cover Date: 1994)

Journal Editor: Pohl U. (Munich), Meininger G.A. (Columbia, Mo.)
ISSN: 1018–1172 (Print), eISSN: 1423–0135 (Online)

For additional information: http://www.karger.com/JVR


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