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Table of Contents
Vol. 34, No. 3, 1997
Issue release date: 1997
Section title: Commentary
J Vasc Res 1997;34:212–219
(DOI:10.1159/000159225)

Mechanotransduction in Endothelial Cells: Temporal Signaling Events in Response to Shear Stress

Takahashi M. · Ishida T. · Traub O. · Corson M.A. · Berk B.C.
Division of Cardiology, Department of Medicine, University of Washington School of Medicine, Seattle, Wash., USA

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Article / Publication Details

First-Page Preview
Abstract of Commentary

Received: 10/23/1996
Accepted: 12/18/1996
Published online: 9/24/2008
Issue release date: 1997

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR

Abstract

Fluid shear stress is one of the most important mechanical forces acting upon vascular endothelium, because of its location at the interface between the bloodstream and vascular wall. Recent evidence indicates that several intracellular signaling events are stimulated in endothelial cells in response to shear stress. Through these events, shear stress modulates endothelial cell function and vascular structure, but the molecular basis of shear stress mechanotransduction remains to be elucidated. In our research we have focused on three temporal signal responses to shear stress: (1) production of nitric oxide (NO) as an immediate response; (2) activation of extracellular-regulated kinases (ERK1/2; p44/p42 mitogen-activated protein (MAP) kinases) as a rapid response, and (3) tyrosine phosphorylation of focal adhesion kinase (FAK) as a sustained response. In terms of vessel biology, NO production, and ERK1/2 and FAK activation seem to be correlated with vascular homeostasis, gene expression and cytoskeletal rearrangement, respectively. In this review, we discuss the mechanisms that establish the temporal order of shear stress-stimulated responses based on a hierarchy for assembly of signal transduction molecules at the cell plasma membrane.

© 1997 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Commentary

Received: 10/23/1996
Accepted: 12/18/1996
Published online: 9/24/2008
Issue release date: 1997

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR


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