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Streptococcus mutans and Streptococcus sanguinis Colonization Correlated with Caries Experience in ChildrenGe Y.a · Caufield P.W.b · Fisch G.S.c · Li Y.a
Departments of aBasic Science and Craniofacial Biology, bCariology and Comprehensive Care and cEpidemiology and Health Promotion, New York University College of Dentistry, New York, N.Y., USA Corresponding Author
Dr. Yihong Li
New York University College of Dentistry
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The aim of this study was to examine the colonization of Streptococcus mutans and Streptococcus sanguinis in the oral cavity and the association with severe early childhood caries (S-ECC). Saliva and plaque samples were collected from 14 S-ECC children and 8 caries-free (CF) children. All S-ECC children were S. mutans positive; 100% of CF children and 93% of S-ECC children were S. sanguinis positive. The children’s caries severity was positively correlated with levels of S. mutans (p < 0.001), total oral streptococci (p < 0.01), total cultivable oral bacteria (p < 0.05), and children’s age (p < 0.05). Logistic regression analysis showed that the interaction of S. sanguinis with S. mutans was a significant factor associated with the caries status in children, suggesting that the relative levels of these two microorganisms in the oral cavity play an important role in caries development.
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