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Vol. 26, No. 4, 2008
Issue release date: October 2008
Section title: Original Research Article
Dement Geriatr Cogn Disord 2008;26:306–313
(DOI:10.1159/000161055)

Neural Correlates of the Clock Drawing Test Performance in Alzheimer’s Disease: A FDG-PET Study

Lee D.Y. · Seo E.H. · Choo I.H. · Kim S.G. · Lee J.S. · Lee D.S. · Jhoo J.H. · Kim K.W. · Youn J.C. · Woo J.I.
aDepartment of Neuropsychiatry and Clinical Research Institute, and bDepartment of Nuclear Medicine, Seoul National University Hospital, and cNeuroscience Research Institute, Medical Research Center and dInterdisciplinary Program in Cognitive Science, Seoul National University, Seoul, Departments of Psychiatry, eSoon Chun Hyang University Hospital, Bucheon, and fKangwon National University Hospital, Chuncheon, and Departments of Neuropsychiatry, gSeoul National University Bundang Hospital, Seongnam, and hKyunggi Provincial Hospital for the Elderly, Yongin, Korea

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 6/30/2008
Published online: 10/8/2008

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Background/Aim: This study aimed to identify the functional neuroanatomical correlates of impaired clock drawing test (CDT) performance in patients with Alzheimer’s disease (AD). Method: The CDT was administered to 71 patients with AD, and regional cerebral glucose metabolism (rCMglc) was measured by positron emission tomography (PET). Correlations between CDT scores and rCMglc were examined on a voxel-by-voxel basis. Results: Significant positive correlations were found between CDT performance and rCMglc in the right inferior parietal lobule and right posterior cingulate cortex. Conclusion: These results provide the first PET evidence that poor CDT performance in patients with AD is closely related to the functional decline in the right hemisphere, especially the right parietal cortex.


  

Author Contacts

Jong Inn Woo
Department of Neuropsychiatry, Seoul National University
College of Medicine and Seoul National University Hospital
28 Yongon-dong, Chongno-gu, Seoul 110-744 (Korea)
Tel. +82 2 760 2456, Fax +82 2 762 3176, E-Mail jiwoomd@snu.ac.kr

  

Article Information

Accepted: June 30, 2008
Published online: October 8, 2008
Number of Print Pages : 8
Number of Figures : 3, Number of Tables : 3, Number of References : 31

  

Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 26, No. 4, Year 2008 (Cover Date: October 2008)

Journal Editor: Chan-Palay V. (New York, N.Y.)
ISSN: 1420–8008 (Print), eISSN: 1421–9824 (Online)

For additional information: http://www.karger.com/DEM


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 6/30/2008
Published online: 10/8/2008

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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