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Vol. 82, No. 4, 2008
Issue release date: November 2008
Section title: Original Paper
Pharmacology 2008;82:270–275
(DOI:10.1159/000161128)

Comparison of the Potency of Different Brands of Serenoa Repens Extract on 5α-Reductase Types I and II in Prostatic Co-Cultured Epithelial and Fibroblast Cells

Scaglione F. · Lucini V. · Pannacci M. · Caronno A. · Leone C.
Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/2/2008
Accepted: 7/4/2008
Published online: 10/10/2008
Issue release date: November 2008

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA

Abstract

Background:Serenoa repens extract is the phytotherapeutic agent most frequently used for the treatment of the urological symptoms caused by benign prostatic hyperplasia. There are many extracts in the market and each manufacturer uses different extraction processes; for this reason, it’s possible that one product is not equivalent to another. The aim of this study was to compare the activity of different extracts of Serenoa repens marketed in Italy. Methods: The following extracts were tested on 10 day co-cultured epithelial and fibroblast cells by a 5α-reductase activity assay: Permixon®, Saba®, Serpens®, Idiprost®, Prostamev®, Profluss® and Prostil®. In order to assess the variability in Serenoa repens products, 2 different batches for each brand were evaluated. Results and Conclusions: All extracts tested, albeit variably, are able to inhibit both isoforms of 5α-reductase. However, the potency of the extracts appears to be very different, as well as the potencies of 2 different batches of the same extract. This is probably due to qualitative and quantitative differences in the active ingredients. So, the product of each company must be tested to evaluate the clinical efficacy and bioactivity.

© 2008 S. Karger AG, Basel


  

Author Contacts

Francesco Scaglione, MD, PhD
Department of Pharmacology, Chemotherapy, and Toxicology
Via Vanvitelli No. 32
IT–20129 Milano (Italy)
Tel. +39 0250 317 073, Fax +39 0250 3150, E-Mail francesco.scaglione@unimi.it

  

Article Information

Received: May 2, 2008
Accepted: July 4, 2008
Published online: October 10, 2008
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 2, Number of References : 19

  

Publication Details

Pharmacology (International Journal of Experimental and Clinical Pharmacology)

Vol. 82, No. 4, Year 2008 (Cover Date: November 2008)

Journal Editor: Donnerer J. (Graz), Billingsley M.L. (Hershey, Pa.), Maeyama K. (Matsuyama)
ISSN: 0031–7012 (Print), eISSN: 1423–0313 (Online)

For additional information: http://www.karger.com/PHA


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/2/2008
Accepted: 7/4/2008
Published online: 10/10/2008
Issue release date: November 2008

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA


Copyright / Drug Dosage

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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