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Vol. 148, No. 3, 2009
Issue release date: February 2009
Section title: Original Paper
Int Arch Allergy Immunol 2009;148:175–185
(DOI:10.1159/000161578)

Therapeutic Effect of Kakkonto in a Mouse Model of Food Allergy with Gastrointestinal Symptoms

Yamamoto T.a · Fujiwara K.a · Yoshida M.a · Kageyama-Yahara N.a · Kuramoto H.c · Shibahara N.b · Kadowaki M.a
aDivision of Gastrointestinal Pathophysiology and bDepartment of Kampo Diagnostics, Institute of Natural Medicine, University of Toyama, Toyama, and cDepartment of Applied Biology, Kyoto Institute of Technology, Kyoto, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/27/2007
Accepted: 5/20/2008
Published online: 10/10/2008
Issue release date: February 2009

Number of Print Pages: 11
Number of Figures: 6
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Background: The number of patients with food allergy has increased dramatically over the last several decades. However, there is no effective drug for food allergies. In the present study, we evaluated the effects of kakkonto, a traditional Japanese herbal medicine, in a mouse model of food allergy with gastrointestinal symptoms. Methods: BALB/c mice were systemically sensitized twice with ovalbumin (OVA) and then were repeatedly given OVA by oral intubation (OVA mice). Kakkonto was administered orally before the OVA challenges. Results: The OVA mice developed allergic diarrhea (91.8 ± 3.8% after 6 OVA challenges), and myeloperoxidase (MPO) activity was dramatically elevated in the colons of the OVA mice. Kakkonto significantly suppressed the occurrence of allergic diarrhea and MPO activity in the OVA mice. Furthermore, the number of mucosal mast cells was greatly increased in the proximal colons of the OVA mice, and this was also suppressed by kakkonto. Interestingly, mRNA expression of helper T cell type 1 (Th1) cytokines (IFN-γ) and Th2 cytokines (IL-4, IL-5 and IL-10) were significantly upregulated in the proximal colons of the OVA mice, an effect which was also reduced by kakkonto. Transcriptome analysis detected increased mRNA expression of suppressor of cytokine signaling-3 in the proximal colons of OVA mice, which was decreased by kakkonto administration. Conclusion: Kakkonto has immunosuppressive effects and interferes with the infiltration of mucosal mast cells in the colons of mice with induced food allergy, leading to improvement of allergic symptoms. Kakkonto has potential as a therapeutic drug for treatment of allergic symptoms induced by the disruption of intestinal mucosal immunity.

© 2008 S. Karger AG, Basel


  

Article Information

Received: December 27, 2007
Accepted after revision: May 20, 2008
Published online: October 10, 2008
Number of Print Pages : 11
Number of Figures : 6, Number of Tables : 1, Number of References : 45

  

Publication Details

International Archives of Allergy and Immunology

Vol. 148, No. 3, Year 2009 (Cover Date: February 2009)

Journal Editor: Valenta R. (Vienna)
ISSN: 1018–2438 (Print), eISSN: 1423–0097 (Online)

For additional information: http://www.karger.com/IAA


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/27/2007
Accepted: 5/20/2008
Published online: 10/10/2008
Issue release date: February 2009

Number of Print Pages: 11
Number of Figures: 6
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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