Objective: To determine from a large cohort of women eligible for screening mammography, the number who would meet criteria for genetic testing for hereditary nonpolyposis colorectal cancer (HNPCC). Methods: Detailed personal and family cancer histories, obtained from 6,682 women aged 50–80 years randomly selected from communities in Washington State, were matched to the Amsterdam criteria, Bethesda guidelines, and Japanese criteria for HNPCC. Results: One (0.015%) respondent met the Amsterdam criteria, 2 (0.035%) met the Japanese criteria and 5 (0.075%) met the Bethesda guidelines. Conclusion: Using the time of presentation for initial mammography as an opportunity to screen for HNPCC would detect very few families at high risk for this condition.
Scott D. Ramsey
Center for Cost and Outcomes Research, University of Washington
146 North Canal Street, Suite 300
Seattle, WA 98103 (USA)
Tel. +1 206 543 4943, Fax +1 206 543 5318, E-Mail firstname.lastname@example.org
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 5, Number of References : 29
Vol. 2, No. 4, Year 1999 (Cover Date: Released June 2000)
Journal Editor: L.P. ten Kate, Amsterdam
ISSN: 1422–2795 (print), 1422–2833 (Online)
For additional information: http://www.karger.com/journals/cmg
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