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Vol. 52, No. 3, 1984
Issue release date: 1984
Section title: Paper
Expl Cell Biol 1984;52:159–169
(DOI:10.1159/000163256)

The Localization and Secretion of Type IV Collagen in Synovial Capillaries by Immunohistochemistry Using a Monoclonal Antibody against Human Type IV Collagen

Matsubara T. · Trüeb B. · Fehr K. · Rüttner J.R. · Odermatt B.F.
Department of aPathology and bRheumatology, University Hospital, Zürich, Switzerland

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 5/30/1983
Accepted: 6/23/1983
Published online: 10/7/2008

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 1015-2008 (Print)
eISSN: 1423-0291 (Online)

For additional information: http://www.karger.com/PAT

Abstract

The localization and the secretion of type IV collagen in synovial capillaries have been investigated by detecting the antigenic determinant of the major triple helix of human type IV collagen. Type IV collagen was indicated to be localized mainly in the lamina densa of basement membranes (BM) and to be secreted by both endothelial cells and pericytes. The pericytes secreted this collagen to both surfaces facing endothelial cells and the interstitial connective tissue. On the contrary, the direction of type IV collagen secretion by the endothelial cells was strictly confined to one side, namely towards the surface facing the BM. The absence of the antigenic determinant in rough endoplasmic reticulum and Golgi apparatus of the endothelial cells and pericytes indicated that the major triple helix of type IV collagen is mainly formed in the secretory vesicles after budding from the Golgi apparatus.


  

Author Contacts

Dr. Tsukasa Matsubara, Department of Orthopaedic Surgery, Kobe University School of Medicine, 7 chome, Kusunoki-cho, Chuo-ku, Kobe (Japan)

  

Article Information

Received: May 30, 1983
Accepted: June 23, 1983
Published online: October 07, 2008
Number of Print Pages : 11

  

Publication Details

Pathobiology (Exploring the basis of disease)

Vol. 52, No. 3, Year 1984 (Cover Date: 1984)

Journal Editor: Borisch B. (Geneva), Yasui W. (Hiroshima)
ISSN: 1015–2008 (Print), eISSN: 1423–0291 (Online)

For additional information: http://www.karger.com/PAT


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 5/30/1983
Accepted: 6/23/1983
Published online: 10/7/2008

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 1015-2008 (Print)
eISSN: 1423-0291 (Online)

For additional information: http://www.karger.com/PAT


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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