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Table of Contents
Vol. 10, No. 4, 2000
Issue release date: 2000
Section title: Original Paper
Cell Physiol Biochem 2000;10:203–208
(DOI:10.1159/000016351)

h-sgk Serine-Threonine Protein Kinase as Transcriptional Target of p38/MAP Kinase pathway in HepG2 Human Hepatoma Cells

Waldegger S. · Gabrysch S. · Barth P. · Fillon S. · Lang F.
Institut für Physiologie I, Gmelinstr. 5, D-72076 Tübingen, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: October 28, 2000
Issue release date: 2000

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1015-8987 (Print)
eISSN: 1421-9778 (Online)

For additional information: http://www.karger.com/CPB

Abstract

The human serum and glucocorticoid dependent serine/threonine kinase h-sgk has previously been discovered as cell volume regulated gene. The present study has been performed to elucidate the involvement of p38-kinase in the transcriptional control of h-sgk by osmotic cell shrinkage. The p38-kinase has previously been cloned as the mammalian homologue of HOG1 kinase, which constitutes a part of the osmosensor in the yeast Saccharomyces cerevisiae. Phosphorylated (active) p38-kinase has been estimated with Western blotting, transcription of hsgk using Northern blotting. Both, increase of extracellular NaCl concentration by 50 mmol/l and addition of 10 μmol/l anisomycin increase phosphorylation of the p38-kinase within 5 to 10 minutes. h-sgk transcription is upregulated by addition of 50 mmol/l NaCl and by anisomycin (10 μmol/l), effects completely inhibited by the specific p38-kinase inhibitor, SB 203580 (10 μmol/l). In conclusion, the stimulation of h-sgk transcription by osmotic cell shrinkage is mediated by p38-kinase.

© 2000 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: October 28, 2000
Issue release date: 2000

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1015-8987 (Print)
eISSN: 1421-9778 (Online)

For additional information: http://www.karger.com/CPB


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