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Vol. 63, No. 4, 1995
Issue release date: 1995
Section title: Review
Pathobiology 1995;63:222–238
(DOI:10.1159/000163955)

Primary Cilia in Normal and Pathological Tissues

Wheatley D.N.
Cell Pathology Unit, Department of Pathology, University Medical School, Aberdeen, Scotland, UK

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Article / Publication Details

First-Page Preview
Abstract of Review

Received: 8/2/1995
Accepted: 8/18/1995
Published online: 10/8/2008
Issue release date: 1995

Number of Print Pages: 17
Number of Figures: 0
Number of Tables: 0

ISSN: 1015-2008 (Print)
eISSN: 1423-0291 (Online)

For additional information: http://www.karger.com/PAT

Abstract

The medical literature in pathology contains a surprising number of anecdotal reports of primary cilia, with authors often expressing some incredulity at finding such organelles. In this update of an earlier review, I will argue that primary cilia should by now be regarded as regular cell organelles, not some form of atypical response to unusual circumstances. In all situations in which their presence is essential, they unquestionably act as sensory transducers. Detection by electron microscopy has been the most reliable means until recently, but is time-consuming and slow for any systematic investigation or experimental approach. Immunostaining with an antibody directed against detyrosinated tubulin is rapidly changing the situation, and we can now detect their presence, frequency, disposition and overall characteristics relatively quickly, allowing better statistical analysis and correlations in abnormal physiological and pathological conditions. To be useful and meaningful, comparative studies need a reliable database of information about primary cilia under ‘normal’ circumstances. It is hoped that such work will in itself give much further insight into the general significance of these organelles, especially combined with the more experimental approaches that can now be adopted in the study of their development and function, which looks increasingly promising with the new technological improvements.

© 1995 S. Karger AG, Basel


  

Author Contacts

Denys N. Wheatley, Cell Pathology Unit, Department of Pathology, University Medical School, Aberdeen AB9 2ZD (UK)

  

Article Information

Received: August 2, 1995
Accepted: August 18, 1995
Published online: October 08, 2008
Number of Print Pages : 17

  

Publication Details

Pathobiology (Exploring the basis of disease)

Vol. 63, No. 4, Year 1995 (Cover Date: 1995)

Journal Editor: Borisch B. (Geneva), Yasui W. (Hiroshima)
ISSN: 1015–2008 (Print), eISSN: 1423–0291 (Online)

For additional information: http://www.karger.com/PAT


Article / Publication Details

First-Page Preview
Abstract of Review

Received: 8/2/1995
Accepted: 8/18/1995
Published online: 10/8/2008
Issue release date: 1995

Number of Print Pages: 17
Number of Figures: 0
Number of Tables: 0

ISSN: 1015-2008 (Print)
eISSN: 1423-0291 (Online)

For additional information: http://www.karger.com/PAT


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