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Vol. 64, No. 4, 1996
Issue release date: 1996
Pathobiology 1996;64:204–208
(DOI:10.1159/000164049)
Original Paper

HIV-1 Disease Association with HLA-DQ Antigens in African Americans and Caucasians

Achord A.P.a · Lewis R.E.a · Brackin M.N.a · Henderson H.b · Cruse J.M.a,b
aDepartment of Pathology, and bDepartment of Medicine, University of Mississippi Medical Center, Jackson, Miss. USA Pathobiology 1996;64:204–208 (DOI:10.1159/000164049)

Abstract

Previously, we have shown that CD4 levels in African Americans infected with human immunodeficiency virus-1 (HIV-1) were lower than those in Caucasians. To determine whether or not HLA type is associated with susceptibility to HIV-1 infection, we demonstrated serologically that HLA-DQ6(1) and HLA-DQ7(3) were associated with HIV-1 infection in both African Americans and Caucasians. The present investigation was designed to demonstrate whether or not HLA-DQB1 alleles were associated with HIV-1 infection or protection from infection within these two ethnic groups. Oligonucleotide typing was employed and results were analyzed by χ2 with Fisher’s exact test to compare HLA-DQ marker frequencies in the regional control population (98 African Americans, 143 Caucasians) to the disease population (n = 52; 30 African Americans and 22 Caucasians). We found a statistically significant increased risk of HIV infection associated with HLA-DQB 1*0605 in African Americans, and with HLA-DQB 1*0602 in Caucasians. By contrast, HLA-DQB 1*0603 was associated with protection in Caucasians.

 goto top of outline Author Contacts

Julius M. Cruse, MD, PhD, Department of Pathology, Immunopathology Section, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 (USA)


 goto top of outline Article Information

Received: April 15, 1996
Accepted: July 3, 1996
Published online: October 08, 2008
Number of Print Pages : 5


 goto top of outline Publication Details

Pathobiology (Exploring the basis of disease)

Vol. 64, No. 4, Year 1996 (Cover Date: 1996)

Journal Editor: Borisch B. (Geneva), Yasui W. (Hiroshima)
ISSN: 1015–2008 (Print), eISSN: 1423–0291 (Online)

For additional information: http://www.karger.com/PAT


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