Previously, we have shown that CD4 levels in African Americans infected with human immunodeficiency virus-1 (HIV-1) were lower than those in Caucasians. To determine whether or not HLA type is associated with susceptibility to HIV-1 infection, we demonstrated serologically that HLA-DQ6(1) and HLA-DQ7(3) were associated with HIV-1 infection in both African Americans and Caucasians. The present investigation was designed to demonstrate whether or not HLA-DQB1 alleles were associated with HIV-1 infection or protection from infection within these two ethnic groups. Oligonucleotide typing was employed and results were analyzed by χ
with Fisher’s exact test to compare HLA-DQ marker frequencies in the regional control population (98 African Americans, 143 Caucasians) to the disease population (n = 52; 30 African Americans and 22 Caucasians). We found a statistically significant increased risk of HIV infection associated with HLA-DQB 1*0605 in African Americans, and with HLA-DQB 1*0602 in Caucasians. By contrast, HLA-DQB 1*0603 was associated with protection in Caucasians.
Julius M. Cruse, MD, PhD, Department of Pathology, Immunopathology Section, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 (USA)
Received: April 15, 1996
Accepted: July 3, 1996
Published online: October 08, 2008
Number of Print Pages : 5
Pathobiology (Exploring the basis of disease)
Vol. 64, No. 4, Year 1996 (Cover Date: 1996)
Journal Editor: Borisch B. (Geneva), Yasui W. (Hiroshima)
ISSN: 1015–2008 (Print), eISSN: 1423–0291 (Online)
For additional information: http://www.karger.com/PAT
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