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Vol. 113, No. 1, 2009
Issue release date: March 2009
Section title: Original Research
Cardiology 2009;113:12–19
(DOI:10.1159/000164149)

Impact of Intravenous Loop Diuretics on Outcomes of Patients Hospitalized with Acute Decompensated Heart Failure: Insights from the ADHERE Registry

Peacock W.F. · Costanzo M.R. · De Marco T. · Lopatin M. · Wynne J. · Mills R.M. · Emerman C.L.
aDepartment of Emergency Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio, bMidwest Heart Foundation, Lombard, Ill., cDivision of Cardiology, University of California, San Francisco, Calif., dScios Inc., Fremont, Calif., and eDepartment of Emergency Medicine, Case Western Reserve University, Cleveland, Ohio, USA

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Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: 1/23/2008
Accepted: 6/20/2008
Published online: 10/17/2008

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 4

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD

Abstract

The optimal use of diuretics in decompensated heart failure remains uncertain. We analyzed data from the ADHERE registry to look at the impact of diuretic dosing. 62,866 patients receiving <160 mg and 19,674 patients ≥160 mg of furosemide were analyzed. The patients receiving the lower doses had a lower risk for in-hospital mortality, ICU stay, prolonged hospitalization, or adverse renal effects. These findings suggest that future studies should evaluate strategies for minimizing exposure to high doses of diuretics.


  

Author Contacts

Charles L. Emerman, MD
Case Western Reserve University
BG353, 2500 MetroHealth Drive
Cleveland, OH 44109 (USA)
Tel. +1 216 778 3577, Fax +1 216 778 3538, E-Mail cemerman@metrohealth.org

  

Article Information

Received: January 23, 2008
Accepted after revision: June 20, 2008
Published online: October 17, 2008
Number of Print Pages : 8
Number of Figures : 2, Number of Tables : 4, Number of References : 32

  

Publication Details

Cardiology (International Journal of Cardiovascular Medicine, Surgery, Pathology and Pharmacology)

Vol. 113, No. 1, Year 2009 (Cover Date: March 2009)

Journal Editor: Borer J.S. (New York, N.Y.)
ISSN: 0008–6312 (Print), eISSN: 1421–9751 (Online)

For additional information: http://www.karger.com/CRD


Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: 1/23/2008
Accepted: 6/20/2008
Published online: 10/17/2008

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 4

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


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