The caries–inhibiting effect of the extract from shiitake (Lentinus edodes), the most popular edible mushroom in Japan, was studied both in vitro and in vivo. Shiitake extract showed an inhibitory effect on water–insoluble glucan formation from sucrose by crude glucosyltransferases of Streptococcus mutans JC–2 and Streptococcus sobrinus OMZ–176. The firmly adherent plaque in the artificial plaque formation test was strongly inhibited by shiitake extract. The reduction of firmly adherent plaque caused an increase in the incidence of non– and loosely adherent plaque and a decrease in total plaque formation. A significantly lower caries score was observed in specific pathogen–free rats infected with S. mutans JC–2 and fed with a cariogenic diet containing 0.25% shiitake extract as compared with controls fed the cariogenic diet without shiitake extract.
Department of Microbiology, Nihon University School of Dentistry at Matsudo
Matsudo City, Chiba 271–8587 (Japan)
Tel. +81 47–360–9342, Fax +81 47–364–6295, E–Mail email@example.com–u.ac.jp
Received: Received: March 23, 1999
Accepted after revision: June 17, 1999
Number of Print Pages : 5
Number of Figures : 2, Number of Tables : 2, Number of References : 24
Caries Research (Journal of the European Organization for Caries Research (ORCA))
Journal founded 1967 by Y. Ericsson; edited 1970–1987 by K.G. König; 1987–1994 by J.M. ten Cate
Vol. 34, No. 1, Year 2000 (Cover Date: January-February 2000)
Journal Editor: J. Tenovuo, Turku
ISSN: 0008–6568 (print), 1421–976X (Online)
For additional information: http://www.karger.com/journals/cre
Article / Publication Details
Published online: 12/17/1999
Issue release date: January–February 2000
Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 2
ISSN: 0008-6568 (Print)
eISSN: 1421-976X (Online)
For additional information: http://www.karger.com/CRE
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.