The caries–inhibiting effect of the extract from shiitake (Lentinus edodes), the most popular edible mushroom in Japan, was studied both in vitro and in vivo. Shiitake extract showed an inhibitory effect on water–insoluble glucan formation from sucrose by crude glucosyltransferases of Streptococcus mutans JC–2 and Streptococcus sobrinus OMZ–176. The firmly adherent plaque in the artificial plaque formation test was strongly inhibited by shiitake extract. The reduction of firmly adherent plaque caused an increase in the incidence of non– and loosely adherent plaque and a decrease in total plaque formation. A significantly lower caries score was observed in specific pathogen–free rats infected with S. mutans JC–2 and fed with a cariogenic diet containing 0.25% shiitake extract as compared with controls fed the cariogenic diet without shiitake extract.
Department of Microbiology, Nihon University School of Dentistry at Matsudo
Matsudo City, Chiba 271–8587 (Japan)
Tel. +81 47–360–9342, Fax +81 47–364–6295, E–Mail email@example.com–u.ac.jp
Received: Received: March 23, 1999
Accepted after revision: June 17, 1999
Number of Print Pages : 5
Number of Figures : 2, Number of Tables : 2, Number of References : 24
Caries Research (Journal of the European Organization for Caries Research (ORCA))
Journal founded 1967 by Y. Ericsson; edited 1970–1987 by K.G. König; 1987–1994 by J.M. ten Cate
Vol. 34, No. 1, Year 2000 (Cover Date: January-February 2000)
Journal Editor: J. Tenovuo, Turku
ISSN: 0008–6568 (print), 1421–976X (Online)
For additional information: http://www.karger.com/journals/cre
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