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Table of Contents
Vol. 55, No. 1, 2009
Issue release date: December 2008
Section title: Experimental Chemotherapy
Chemotherapy 2009;55:6–10
(DOI:10.1159/000166383)

Quercetin Is Able to Demethylate the p16INK4a Gene Promoter

Tan S. · Wang C. · Lu C. · Zhao B. · Cui Y. · Shi X. · Ma X.
aReproductive and Genetic Center of the National Research Institute for Family Planning, bGraduate School, Peking Union Medical College, and cWorld Health Organization Collaborating Centre for Research in Human Reproduction, Beijing, and dResearch Institute for Family Planning in Hunan Province, Changsha, China

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Article / Publication Details

First-Page Preview
Abstract of Experimental Chemotherapy

Received: 2/29/2008
Accepted: 6/27/2008
Published online: 10/31/2008

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 2

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: http://www.karger.com/CHE

Abstract

Background: Quercetin is a flavonoid found ubiquitously in nature. Studies in vitroand in vivohave suggested that quercetin may have a protective role against colon cancer. Methods: We selected the human colon cancer cell line RKO to investigate the effects of quercetin in vitro. RKO cells were treated with different concentrations of quercetin. Results: In comparison to the control, quercetin was able to inhibit the growth of RKO cells, as measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Untreated RKO cells demonstrated almost complete methylation of the p16INK4a gene. Hypermethylation of the p16INK4a gene was successfully reversed after 120 h of treatment with quercetin. Expression of the p16INK4a gene was restored in a concentration-dependent manner. Conclusion: All these data suggest that quercetin has antitumor properties, probably via demethylation of the p16INK4a gene promoter.


  

Author Contacts

Prof. Xu Ma
Center for Genetics, National Research Institute for Family Planning
12 Dahuisi Road, Haidian
Beijing 100081 (China)
Tel. +86 10 6217 6870, Fax +86 10 6217 9059, E-Mail lovebintsn@hotmail.com

  

Article Information

S.T. and C.W. contributed equally to this paper.

Received: February 29, 2008
Accepted after revision: June 27, 2008
Published online: October 31, 2008
Number of Print Pages : 5
Number of Figures : 3, Number of Tables : 2, Number of References : 27

  

Publication Details

Chemotherapy (International Journal of Experimental and Clinical Chemotherapy)

Vol. 55, No. 1, Year 2009 (Cover Date: December 2008)

Journal Editor: Sörgel F. (Nürnberg-Heroldsberg)
ISSN: 0009–3157 (Print), eISSN: 1421–9794 (Online)

For additional information: http://www.karger.com/CHE


Article / Publication Details

First-Page Preview
Abstract of Experimental Chemotherapy

Received: 2/29/2008
Accepted: 6/27/2008
Published online: 10/31/2008

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 2

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: http://www.karger.com/CHE


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