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Table of Contents
Vol. 27, No. 1, 2009
Issue release date: January 2009
Section title: Paper
Blood Purif 2009;27:86–91
(DOI:10.1159/000167015)

New Insights into Lipid Metabolism in Chronic Kidney Disease: What Are the Practical Implications?

Kaysen G.A.
Division of Nephrology, Departments of Medicine and of Biochemistry and Molecular Medicine, UC Davis, Davis, Calif., and Department of Veterans Affairs, Northern California Health Care System, Mather, Calif., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: January 23, 2009
Issue release date: January 2009

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 0

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: http://www.karger.com/BPU

Abstract

The risk of cardiovascular disease increases with declining glomerular filtration rate. Hyperlipidemia and dyslipidemia, characterized by increased triglycerides and low levels of high-density lipoprotein, are both associated with cardiovascular outcome as well as the risk of progression of loss of renal function. Both hyperlipidemia and dyslipidemia respond to pharmacologic therapy, including hydroxymethylglutaryl-CoA reductase inhibitors and fibric acid derivatives, to alteration in diet as well as to extreme measures such as bariatric surgery. However, the effects of these modalities on cardiovascular or renal outcomes are dependent upon the level of renal function. There is strong evidence that patients with stages 1–3 chronic kidney disease attain benefit from lipid-lowering therapy both with reduction in cardiovascular risk and possibly reduction in the rate of decline in renal function. Among dialysis patients little risk reduction appears to be achieved by treatment of low-density lipoprotein cholesterol level. Bariatric surgery reduces hyperlipidemia in patients with chronic kidney disease, but has also been associated with subsequent rapid decline in renal function secondary to oxalate deposition.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: January 23, 2009
Issue release date: January 2009

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 0

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: http://www.karger.com/BPU


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