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Vol. 110, No. 3, 2008
Issue release date: November 2008
Section title: Original Paper
Nephron Clin Pract 2008;110:c185
(DOI:10.1159/000167271)

A Randomized Trial of Low-Animal-Protein or High-Fiber Diets for Secondary Prevention of Calcium Nephrolithiasis

Dussol B. · Iovanna C. · Rotily M. · Morange S. · Leonetti F. · Dupuy P. · Vazi A. · Saveanu A. · Loundou A. · Berland Y.
aCentre de Néphrologie et de Transplantation Rénale, Assistance Publique, Hôpitaux de Marseille, Université Aix-Marseille II, bCentre d’Investigations Cliniques, Assistance Publique, Hôpitaux de Marseille et INSERM, cORS PACA-INSERM U379, et dUnité d’Aide Méthodologique, Université Aix-Marseille II, Marseille, et eService de Néphrologie, CHG Saint Brieuc, Saint-Brieuc, France

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/11/2008
Accepted: 7/22/2008
Published online: 10/29/2008

Number of Print Pages: 1
Number of Figures: 2
Number of Tables: 8

ISSN: (Print)
eISSN: 1660-2110 (Online)

For additional information: http://www.karger.com/NEC

Abstract

Background: The purpose of this trial was to evaluate the efficacy of a low-animal-protein diet (LAPD) or a high-fiber diet (HFD) for the prevention of calcium nephrolithiasis recurrence. Methods: We conducted a 4-year randomized trial comparing the effect of 2 diets in 175 idiopathic calcium stone formers. Fifty-five were assigned to a LAPD (<13% of total energy derived from protein), 60 were assigned to a HFD (>25 g/day fiber) and 60 were placed on a normal diet (control group). The primary outcome measure was the time to the first recurrence of calcium nephrolithiasis. Daily urine compositions were analyzed at baseline, at month 4 (M4), M12, M24, M36 and M48. Results: Seventy-three patients completed the trial (23 in the LAPD group, 27 in the HFD group and 23 in the control group). Recurrence was 48% (11/23) in the LAPD group, 63% (17/27) in the HFD group and 48% (11/23) in the control group (p = not significant). During follow-up, urinary calcium levels and other urine parameters did not change significantly in the 3 groups, except for a significant decrease in 24-hour urinary sulfate in the LAPD group. Conclusions: In idiopathic calcium stone formers, neither a LAPD nor a HFD appeared to provide protection against recurrence.


  

Author Contacts

Prof. Bertrand Dussol
Centre de Néphrologie et de Transplantation Rénale
Hôpital de la Conception, 147, Bd Baille
FR–13385 Marseille Cedex 05 (France)
Tel. +33 4 9138 3043, Fax +33 4 9138 3206, E-Mail bdussol@ap-hm.fr

  

Article Information

Received: March 11, 2008
Accepted: July 22, 2008
Published online: October 29, 2008
Number of Print Pages : 10
Number of Figures : 2, Number of Tables : 8, Number of References : 33

  

Publication Details

Nephron Clinical Practice

Vol. 110, No. 3, Year 2008 (Cover Date: November 2008)

Journal Editor: El Nahas M. (Sheffield)
ISSN: 1660–2110 (Print), eISSN: 1660–2110 (Online)

For additional information: http://www.karger.com/NEC


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/11/2008
Accepted: 7/22/2008
Published online: 10/29/2008

Number of Print Pages: 1
Number of Figures: 2
Number of Tables: 8

ISSN: (Print)
eISSN: 1660-2110 (Online)

For additional information: http://www.karger.com/NEC


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