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Table of Contents
Vol. 122, No. 3-4, 2008
Issue release date: February 2009
Section title: Telomerase and Alternative Lengthening of Telomeres
Cytogenet Genome Res 122:263–272 (2008)
(DOI:10.1159/000167812)

Telomerase regulation at the crossroads of cell fate

Çukušić A.a · Škrobot Vidaček N.a · Sopta M.b · Rubelj I.a
aLaboratory of Experimental Cancerology, bLaboratory for Gene Regulation, Department of Molecular Biology, Ruđer Bošković Institute, Zagreb (Croatia)

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Article / Publication Details

First-Page Preview
Abstract of Telomerase and Alternative Lengthening of Telomeres

Accepted: July 16, 2008
Published online: January 30, 2009
Issue release date: February 2009

Number of Print Pages: 10
Number of Figures: 2
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

Telomeres are specialized structures at the ends of eukaryotic chromosomes and are crucial for genome stability, cell growth control and carcinogenesis. Normally, they protect chromosomes from end to end fusion, degradation and recombination. Telomerase is a ribonucleoprotein essential for maintenance of telomeres and it is active in germ cells, stem cells and ∼90% of cancers but not in most normal somatic cells. Human telomerase catalytic protein subunit hTERT is crucial for telomerase activity. Although hTERT expression is sufficient to immortalize normal human cells in culture, spontaneous immortalization is extremely rare which suggests that its expression is under strong negative control. Characterization of the hTERT promoter has allowed for the analysis of potential mechanisms of hTERT expression and regulation. The hTERT promoter is very complex and contains a great number of canonical and non-canonical sequences that bind or potentially bind a variety of transcription factors. In this review we focus on the positive and negative regulators of hTERT transcription and their role in normal cell growth and immortalization.

© 2008 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Telomerase and Alternative Lengthening of Telomeres

Accepted: July 16, 2008
Published online: January 30, 2009
Issue release date: February 2009

Number of Print Pages: 10
Number of Figures: 2
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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