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Table of Contents
Vol. 11, No. 5, 1991
Issue release date: 1991
Section title: Clinical Study
Am J Nephrol 1991;11:363–368
(DOI:10.1159/000168339)

Effect of Hemodialysis on the Concentration of the Seven Tumor Markers Carcinoembryonic Antigen, Alpha-Fetoprotein, Squamous Cell Carcinoma-Related Antigen, Neuron-Specific Enolase, CA 125, CA19–9 and CA 15–3 in Uremic Patients

Odagiri E.a · Jibiki K.a · Takeda M.a · Sugimura H.a · Iwachika C.a · Abe Y.a · Kihara K.a · Kihara Y.a · Itou M.a · Nomura T.a · Kubo K.b · Sugino N.b · Ohta K.b · Demura R.a · Demura H.a
aRadioassay Center and bKidney Center, Tokyo Womens’ Medical College, Tokyo, Japan

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 7/27/1990
Accepted: 7/26/1991
Published online: 10/28/2008
Issue release date: 1991

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN

Abstract

The incidence of the 7 tumor markers carcinoembryonic antigen (CEA), α-fetoprotein (AFP), squamous cell carcinoma-related antigen (SCC), neuron-specific enolase (NSE), CA 125, CA 19–9 and CA 15–3 was studied before and after hemodialysis (HD) in 144 uremic patients who had no malignancies. Before HD, of all tumor markers, the mean concentration of SCC only exceeded the normal value. The positive rate was highest in SCC (95.1 %), and that of CEA and NSE was 25.7 and 10.6%, respectively. However, AFP was within the normal range in all cases. Among CA antigens, the positive rate of CA 125 was 7.6%, of CA 19–9 was 6.3% and of CA 15–3 was 3.5%. After HD, the incidence as well as the mean concentration of all tumor markers increased. A parallel increment of total protein was observed after HD. The membrane filter used in HD appears to be insufficient to remove tumor marker proteins during HD. It is necessary to consider the clinical interpretation of elevated tumor markers in patients with uremia.

© 1991 S. Karger AG, Basel


  

Author Contacts

Emi Odagiri, Radioassay Center, Tokyo Womens’ Medical College, 8-1, Kawadacho, Shinjuku-ku, Tokyo 162 (Japan)

  

Article Information

Received: July 27, 1990
Accepted: July 26, 1991
Published online: October 28, 2008
Number of Print Pages : 6

  

Publication Details

American Journal of Nephrology

Vol. 11, No. 5, Year 1991 (Cover Date: 1991)

Journal Editor: Bakris G. (Chicago, Ill.)
ISSN: 0250–8095 (Print), eISSN: 1421–9670 (Online)

For additional information: http://www.karger.com/AJN


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 7/27/1990
Accepted: 7/26/1991
Published online: 10/28/2008
Issue release date: 1991

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN


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