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Vol. 13, No. 6, 1993
Issue release date: 1993
Am J Nephrol 1993;13:464–466
(DOI:10.1159/000168664)
Clinical Study

Erythrocyte Vitamins B1, B2 and B6 and Erythropoietin

Mydlík M. · Derzsiová K.
Fourth Medical Clinic, University Hospital of Louis Pasteur, Košice, Slovak Republic

Abstract

The influence of recombinant human erythropoietin (r-HuEPO) on erythrocyte vitamins Bi, B2 and B6 was investigated in regular dialysis treatment (RDT) patients during a long-term 9-month study. Twenty-six RDT patients were divided into two groups. Group A was without r-HuEPO treatment while group B was treated by subcutaneous injection of r-HuEPO. The total maintenance weekly dose of r-HuEPO was 50-100 U/kg. Group A of patients was supplemented with oral pyridoxine 5 mg/day during the period of 9 months; group B was supplemented with oral pyridoxine 5 mg/day for the first 6 months and with 20 mg/day during the following 3 months. At the end of the study, significant increase in erythrocyte vitamin B2 and significant decrease in erythrocyte vitamin B6 were found. Supplementation with 20 mg/day of pyridoxine led to a significant increase in vitamin B6 and at the end of the 9 months, the values of vitamin B6 were within the normal range. These results provide indirect evidence that erythrocyte vitamin B6 is consumed by the hemoglobin synthesis during r-HuEPO treatment in RDT patients.

 goto top of outline Author Contacts

Prof. Miroslav Mydlík, MUDr, DrSc, Fourth Medical Clinic, University Hospital of Louis Pasteur, Rastislavova 43, 041 90 Košice (Slovak Republic)


 goto top of outline Article Information

Received: May 7, 1993
Accepted: August 27, 1993
Published online: October 28, 2008
Number of Print Pages : 3


 goto top of outline Publication Details

American Journal of Nephrology

Vol. 13, No. 6, Year 1993 (Cover Date: 1993)

Journal Editor: Bakris G. (Chicago, Ill.)
ISSN: 0250–8095 (Print), eISSN: 1421–9670 (Online)

For additional information: http://www.karger.com/AJN


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