Core needle biopsies represent only a small portion of a breast lesion. Rare lesions with overlapping features may be underestimated in such small samples.
A 67-year-old female underwent core needle biopsy of a 27-mm breast tumour demonstrating infiltrative glands without significant desmoplasia. Periglandular collagen IV immunostaining and the small glands were reminiscent of microglandular adenosis, and despite the infiltrative look of the microglands, the lesion was interpreted as suspicious for malignancy. Finally, the tumour proved to be a tubulolobular carcinoma.
The tubules of tubulolobular carcinoma may show a basement membrane-like staining pattern with collagen IV, and this must be considered in the differential diagnosis of mammary lesions with small glandular architecture.
Gábor Cserni, MD, PhD, DSc, Bács-Kiskun County Teaching Hospital, Nyiri ut 38, 6000 Kecskemét, Hungary, Tel./Fax +36 76 516768, firstname.lastname@example.org
Published online: November 25, 2008
Number of Print Pages : 3
Number of Figures : 3, Number of Tables : 0, Number of References : 18
Breast Care (Multidisciplinary Journal for Research, Diagnosis and Therapy)
Vol. 3, No. 6, Year 2008 (Cover Date: December 2008)
Journal Editor: Harbeck N. (München), Jakesz R. (Wien), Thomssen C. (Halle/Saale)
ISSN: 1661–3791 (Print), eISSN: 1661–3805 (Online)
For additional information: http://www.karger.com/BRC
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