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Table of Contents
Vol. 9, No. 2, 1998
Issue release date: March – April
Section title: Original Research Article
Dement Geriatr Cogn Disord 1998;9:68–73
(DOI:10.1159/000017025)

Regional Hypometabolism Related to Language Disturbance in Alzheimer’s Disease

Hirono N.a · Mori E.a · Ishii K.b · Ikejiri Y.a · Imamura T.a · Shimomura T.a · Ikeda M.a · Yamashita H.a · Takatsuki Y.a · Sasaki M.b
Departments of a Clinical Neurosciences and b Neuroimaging Research, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: February 20, 1998
Issue release date: March – April

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

To elucidate the nature of language disturbance in Alzheimer’s disease (AD) and the cerebral area involved in it, we studied 65 AD patients with the Western Aphasia Battery (WAB) and with 18F-fluorodeoxyglucose and positron emission tomography. Partial correlations were evaluated between the Aphasia Quotient of WAB and regional cerebral glucose metabolism normalized by the mean metabolic rate in the bilateral primary sensorimotor areas after controlling age, sex, education and severity of illness. Language disturbance in AD is accounted for by deficits in the semantic processing of language and is related to glucose hypometabolism in the inferior temporal gyrus and inferior parietal lobule, especially in the dominant side. These results offer further evidence suggesting that the lexico-semantic processing system is mediated in these regions.


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: February 20, 1998
Issue release date: March – April

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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