Epidemiologic and Genetic Studies of Dementia of the Alzheimer Type in JapanUrakami K. · Adachi Y. · Wakutani Y. · Isoe K. · Ji Y. · Takahashi K. · Nakashima K.
a Division of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Nishimachi, Yonago, b Tottori University, Tottori, Japan
We carried out two separate epidemiological studies on long-term changes, 10 years apart, on the prevalence rate of dementia in the elderly by the same method for the same area in Japan. We also performed a genetic study of patients with dementia of the Alzheimer type (DAT) based on the epidemiological studies. The number of patients with dementia was much larger in 1990 than in 1980. Especially, the number of mildly demented patients was significantly larger in 1990 than in 1980. The 35 patients with DAT did not show any mutations of amyloid-β protein precursor, presenilin 1 and presenilin 2 genes. The frequency of apolipoprotein E (apo E) σ4 allele in DAT was significantly higher than that in control subjects (p < 0.005). This study suggests that the frequency of DAT may increase by aging of the population in the future and we confirm the close association between apoE σ4 allele and DAT in a community-based study in Japan.
Dr. Katsuya Urakami
Division of Neurology
Institute of Neurological Sciences, Faculty of Medicine
Tottori University, Nishimachi 36-1, Yonago 683-8504 (Japan)
Tel. +81 859 34 8032, Fax +81 859 34 8083, E-Mail firstname.lastname@example.org
Received: Accepted: March 16, 1998
Number of Print Pages : 5
Number of Figures : 8, Number of Tables : 0, Number of References : 24
Dementia and Geriatric Cognitive Disorders
Vol. 9, No. 5, Year 1998 (Cover Date: September-October 1998)
Journal Editor: V. Chan-Palay, New York, N.Y.
ISSN: 1420–8008 (print), 1421–9824 (Online)
For additional information: http://www.karger.com/journals/dem