Simple Standardised NeuropsychologicalAssessments Aid in the Differential Diagnosis of Dementia with Lewy Bodies from Alzheimer’s Disease and Vascular DementiaBallard C.G.a · Ayre G.a · O’Brien J.b · Sahgal A.a · McKeith I.G.b · Ince P.G.a · Perry R.H.b
aMRC Neurochemical Pathology Unit, and bUniversity of Newcastle upon Tyne, Newcastle upon Tyne, UK
Consecutive patients from a dementia case register received a standardised evaluation which incorporated a neuropsychological assessment with the Cambridge Assessment for disorders in the elderly (CAMCOG). Operationalised clinical diagnoses were made (consensus criteria for dementia with Lewy bodies, DLB; NINCDS- ADRDA for Alzheimer’s disease, AD, NINCDS AIRENS for vascular dementia, VaD). Two-hundred and twenty-eight patients were studied (DLB 54, AD102, VaD 72). DLB patients had significantly better performance on recent memory than AD patients, but more impaired visuospatial praxis. DLB patients also had significantly better recent memory than those with VaD. Optimal cut-off points for the recent memory:praxis ratio achieved good discrimination between DLB and both other dementias.
Dr. C.G. Ballard
MRC, Neurochemical Pathology Unit
Newcastle General Hospital, Westgate Rd
Newcastle upon Tyne NE4 6BE (UK)
Tel. +44 0191 273 5251, Fax +44 0191 272 5291, E-Mail firstname.lastname@example.org
Accepted: August 14, 1998
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 3, Number of References : 31
Dementia and Geriatric Cognitive Disorders
Vol. 10, No. 2, Year 1999 (Cover Date: March-April 1999)
Journal Editor: V. Chan-Palay, New York, N.Y.
ISSN: 1420–8008 (print), 1421–9824 (Online)
For additional information: http://www.karger.com/journals/dem