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Vol. 10, No. 3, 1999
Issue release date: May–June 1999
Section title: Review
Dement Geriatr Cogn Disord 1999;10:226–230
(DOI:10.1159/000017124)

Agraphia in Alzheimer’s Disease

Croisile B.
Laboratoire de Neuropsychologie–Fonctions Cognitives, Langage, Mémoire, Hôpital Neurologique, Lyon, France

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Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 5/11/1999
Issue release date: May–June 1999

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Writing disorders are an early manifestation of Alzheimer’s disease (AD), often more severe than language difficulties. AD patients produce shorter and less informative written descriptions of a complex picture than controls. These abbreviated texts also include many intrusions, semantic substitutions, and misspellings. Syntactic difficulties are characterized by a reduction of subordinate clauses rather than by the occurrence of grammatical errors. Lexical spelling is systematically more impaired and affected earlier than phonological spelling. With disease progression, the deficits of central writing processes extend to graphic difficulties and alteration of handwriting spatial organization. In the context of a semiotic hierarchy, an inverse relationship is suggested between writing acquisition during childhood and subsequent writing degradation in AD. The writing disturbance in AD is evidently related to a disruption in the anatomicofunctional cerebral network designed for writing processes, mainly in the parietal regions.


  

Author Contacts

Dr. Bernard Croisile, MD, PhD
Laboratoire de Neuropsychologie–Fonctions Cognitives, Langage, Mémoire
Hôpital Neurologique, 59, bd Pinel
F–69003 Lyon (France)
Tel. +33 472 11 80 66, Fax +33 472 35 78 61

  

Article Information

Accepted: September 26, 1998
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 0, Number of References : 36

  

Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 10, No. 3, Year 1999 (Cover Date: May-June 1999)

Journal Editor: V. Chan-Palay, New York, N.Y.
ISSN: 1420–8008 (print), 1421–9824 (Online)

For additional information: http://www.karger.com/journals/dem


Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 5/11/1999
Issue release date: May–June 1999

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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