Writing disorders are an early manifestation of Alzheimer’s disease (AD), often more severe than language difficulties. AD patients produce shorter and less informative written descriptions of a complex picture than controls. These abbreviated texts also include many intrusions, semantic substitutions, and misspellings. Syntactic difficulties are characterized by a reduction of subordinate clauses rather than by the occurrence of grammatical errors. Lexical spelling is systematically more impaired and affected earlier than phonological spelling. With disease progression, the deficits of central writing processes extend to graphic difficulties and alteration of handwriting spatial organization. In the context of a semiotic hierarchy, an inverse relationship is suggested between writing acquisition during childhood and subsequent writing degradation in AD. The writing disturbance in AD is evidently related to a disruption in the anatomicofunctional cerebral network designed for writing processes, mainly in the parietal regions.
Dr. Bernard Croisile, MD, PhD
Laboratoire de Neuropsychologie–Fonctions Cognitives, Langage, Mémoire
Hôpital Neurologique, 59, bd Pinel
F–69003 Lyon (France)
Tel. +33 472 11 80 66, Fax +33 472 35 78 61
Accepted: September 26, 1998
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 0, Number of References : 36
Dementia and Geriatric Cognitive Disorders
Vol. 10, No. 3, Year 1999 (Cover Date: May-June 1999)
Journal Editor: V. Chan-Palay, New York, N.Y.
ISSN: 1420–8008 (print), 1421–9824 (Online)
For additional information: http://www.karger.com/journals/dem
Article / Publication Details
Published online: 5/11/1999
Issue release date: May–June 1999
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)
For additional information: http://www.karger.com/DEM
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