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Table of Contents
Vol. 10, No. 4, 1999
Issue release date: July–August 1999
Section title: Original Research Article
Dement Geriatr Cogn Disord 1999;10:289–294
(DOI:10.1159/000017134)

A Double-Blind, Placebo-Controlled Study of Tacrine in Chinese Patients with Alzheimer’s Disease

Wong W.-J. · Liu H.-C. · Fuh J.-L. · Wang S.-J. · Hsu L.-C. · Wang P.-N. · Sheng W.-Y.
Neurological Institute, Veterans General Hospital, and Department of Neurology, National Yang-Ming University School of Medicine, Taipei, Taiwan

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: 6/18/1999

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 4

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

The purpose of the study was to evaluate the efficacy and safety of tacrine over 30 weeks in Chinese patients with probable Alzheimer’s disease (AD). A total of 100 patients with mild to moderate AD were recruited and randomly assigned to active or placebo treatment. The active group received 30 mg/day of tacrine for the first 6 weeks, 60 mg/day for the next 6 weeks, 90 mg/day for 6 more weeks and then 120 mg/day for the remaining 12 weeks. Safety evaluations included biweekly determinations of alanine aminotransferase (ALT). The primary outcome measures were Cognitive Abilities Screening Instrument (CASI), Clinical Global Impression of Change (CGIC) by investigator and the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE). Secondary outcome measures were Mini-mental State Examination (MMSE), Alzheimer’s Deficit Scale (ADS) and CGIC by caregivers. Sixty-eight patients were included in an intent-to-treat analysis (48 active and 20 placebo); 56 patients had evaluable data at week 30 (36 active and 20 placebo). The results of the complete case analysis revealed a significant improvement in the CASI and MMSE scores of the active group in the 18th week (90 mg/day) and the 30th week (120 mg/day) (p < 0.01). In the intent-to-treat analysis, significant improvement of the active group was noted on CASI at week 30 (p = 0.05), but there was no significant difference in the measures of IQCODE, CGIC and ADS. The primary reasons for withdrawal of tacrine-treated patients (39 patients, 52%) were asymptomatic ALT elevation, anorexia and nausea/vomiting. These patients all recovered from the adverse events on discontinuation of treatment. Tacrine produced a statistically significant improvement in the CASI and MMSE in Chinese patients with mild to moderate AD using a lower dose than in western people.


  

Author Contacts

Dr. Wen-Jang Wong
Neurological Institute, Veterans General Hospital-Taipei
201, 2nd Sec. Shih-Pai Rd, Taipei, 112 (Taiwan)
Tel. +886 2 28757046, Fax +886 2 28739241
E-Mail wjwong@tpts5.seed.net.tw

  

Article Information

Accepted: November 17, 1998
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 4, Number of References : 22

  

Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 10, No. 4, Year 1999 (Cover Date: July-August 1999)

Journal Editor: V. Chan-Palay, New York, N.Y.
ISSN: 1420–8008 (print), 1421–9824 (Online)

For additional information: http://www.karger.com/journals/dem


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: 6/18/1999

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 4

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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