Blood Levels of Alpha-1-Antichymotrypsin and Risk Factors for Alzheimer’s Disease: Effects of Gender and Apolipoprotein E GenotypeLicastro F. · Masliah E. · Pedrini S. · Thal L.J.
aDipartimento di Patologia Sperimentale, University of Bologna, Italy; and bDepartment of Neuroscience, University of San Diego, La Jolla, Calif., USA
Concentrations of α1-antichymotrypsin (ACT) were measured in serum or plasma samples from 137 patients with late-onset probable Alzheimer’s disease (AD) and 89 controls. Levels of ACT from sera or plasma from both AD or controls were different, being highest in serum samples. Increased levels of serum or plasma ACT and normal levels of C-reactive protein (CRP) were found in AD. Differences in serum ACT levels between AD and controls were statistically significant, while those in plasma ACT were not. ACT serum levels were higher in women with AD that in female and male controls. Apolipoprotein E (APOE) genotypes did not independently affect blood ACT levels in both AD and controls; although, among AD patients, female AD patients with APOE 4,4 showed the highest level of serum ACT. The gender effect appeared to be prominent, since female AD patients with APOE 3,3 had similar ACT levels to those of female AD patients with APOE 4,4.
Prof. F. Licastro
Dipartimento di Patologia Sperimentale, University of Bologna
Via S. Giacomo 14
I–40126 Bologna (Italy)
Tel. +39 051 2094730, Fax +39 051 2094746, E-Mail email@example.com
Accepted: March 12, 1999
Number of Print Pages : 4
Number of Figures : 2, Number of Tables : 1, Number of References : 36
Dementia and Geriatric Cognitive Disorders
Vol. 11, No. 1, Year 2000 (Cover Date: January-February 2000)
Journal Editor: V. Chan-Palay, New York, N.Y.
ISSN: 1420–8008 (print), 1421–9824 (Online)
For additional information: http://www.karger.com/journals/dem