Neuropathological Substrates of Dementia and Depression in Vascular Dementia, with a Particular Focus on Cases with Small Infarct VolumesBallard C. · McKeith I. · O’Brien J. · Kalaria R. · Jaros E. · Ince P. · Perry R.
aMRC Neurochemical Pathology Unit, Newcastle General Hospital and bUniversity of Newcastle upon Tyne, UK
The neuropathological substrates of dementia and depression were evaluated in 30 patients with cerebrovascular disease and significant cognitive impairment (VaD), with a particular focus on patients with small infarct volumes (<15 ml). VaD patients with small infarct volumes had a similar degree of cognitive impairment to those with larger infarct volumes (>15 ml) but were significantly more likely to be depressed and to have areas of microinfarction. A review of individual cases with small infarct volumes suggested that the combination of microinfarction, diffuse white matter disease and perivascular changes, or the overlap of neurodegenerative pathologies and microvascular changes were particularly important. Microinfarction was also significantly associated with major depression.
Dr. Clive Ballard
MRC Neurochemical Pathology Unit, Newcastle General Hospital
Newcastle upon Tyne NE4 6BE (UK)
Tel. +44 191 2735251, Fax +44 191 2725291, E-Mail email@example.com
Accepted: May 15, 1999
Number of Print Pages : 7
Number of Figures : 0, Number of Tables : 3, Number of References : 29
Dementia and Geriatric Cognitive Disorders
Vol. 11, No. 2, Year 2000 (Cover Date: March-April 2000)
Journal Editor: V. Chan-Palay, New York, N.Y.
ISSN: 1420–8008 (print), 1421–9824 (Online)
For additional information: http://www.karger.com/journals/dem