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Table of Contents
Vol. 11, No. 3, 2000
Issue release date: May – June
Section title: Original Research Article
Dement Geriatr Cogn Disord 2000;11:176–180
(DOI:10.1159/000017232)

Alzheimer Disease and Vascular Dementia: Relationships with Fasting Glucose and Insulin Levels

Carantoni M.†,a · Zuliani G.a · Munari M.R.b · D’Elia K.a · Palmieri E.a · Fellin R.a
aDepartment of Internal Medicine II, University of Ferrara School of Medicine, Ferrara, and bLong-Term Care Division, Cà Foncello Hospital, Treviso, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: April 19, 2000
Issue release date: May – June

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Cerebrovascular disease and Alzheimer disease are the leading causes of dementia in elderly subjects. In spite of it, relatively little is known about the pathogenesis and risk factors for dementia. We evaluated fasting plasma glucose and insulin, albumin, lipids, Lp(a) and uric acid levels in nondiabetic patients of both sexes affected by vascular dementia (VD) and senile dementia of the Alzheimer type (SDAT) as well as in a control group of age-matched nondemented subjects. Following a covariance analysis by gender, body mass index, albumin levels and prevalence of arterial hypertension, total and LDL cholesterol as well as HDL cholesterol levels were not significantly different among the three groups. Fasting glucose (p < 0.001 and p < 0.005, respectively) and insulin levels (p < 0.05 for both differences) were higher in patients with VD and SDAT than in control subjects. Our data show that nondiabetic patients with VD or SDAT have higher fasting glucose and insulin levels than healthy control subjects. These metabolic characteristics were not influenced by differences in gender, adiposity, nutritional status, lipids or presence of arterial hypertension.

© 2000 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: April 19, 2000
Issue release date: May – June

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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