Path Analysis Shows That Increasing Ketogenic Ratio, but Not β-Hydroxybutyrate, Elevates Seizure Threshold in the RatBough K.J. · Chen R.S. · Eagles D.A.
Departments of aBiology and bAcademic and Information Technology Services, Washington, D.C., USA
Previous work has identified several criteria that may be important in determining the efficacy of the ketogenic diet as a treatment for intractable epilepsy in children. The present study was designed to investigate the influence of four major variables on seizure threshold, i.e. ketogenic ratio, body weight, age at diet onset and β-hydroxybutyrate in rats. Path analysis was used to statistically model and quantify the causal relationships among variables. Results indicate that seizure threshold was significantly elevated with increasing ketogenic ratios (i.e. more fats vs. carbohydrates and proteins) and decreasing weight. Conversely, age at diet onset and plasma levels of β-OHB showed no causal relation to seizure resistance. These results suggest that the efficacy of the ketogenic diet is independent of the level of ketonemia but is markedly influenced by diet and growth.
Douglas A. Eagles, PhD
Box 571229, Department of Biology, Georgetown University
Washington, DC 20057-1229 (USA)
Tel. +1 202 687 5905, Fax +1 202 687 5662
Received: Received: March 29, 1999
Accepted: May 1, 1999
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 1, Number of References : 35
Vol. 21, No. 3-5, Year 1999 (Cover Date: May-October 1999 (Released November 1999))
Journal Editor: A.T. Campagnoni, Los Angeles, Calif.
ISSN: 0378–5866 (print), 1421–9859 (Online)
For additional information: http://www.karger.com/journals/dne