Diet, Lipids and Brain DevelopmentSalvati S.a · Attorri L.a · Avellino C.a · Di Biase A.a · Sanchez M.b
aNeurochemistry Section, Laboratory of Metabolism and Pathological Biochemistry, bLaboratory of Cell Biology, Istituto Superiore di Sanità, Rome, Italy
Brain development is a sequential anatomical process characterised by specific well-defined stages of growth and maturation. One of the fundamental and necessary events in the normal development of the central nervous system in vertebrates is the formation of a myelin sheath. It is becoming more evident that this process is influenced by dietary lipids. A number of findings have indicated that the administration of a diet deficient in essential fatty acids during development causes hypomyelination in the rat brain. Our studies have shown that lipids can also play a role in accelerating myelinogenesis in the brain of rats whose mothers had been fed, during pregnancy and lactation, a lipid fraction extracted from yeast grown on n-alkanes. Further studies have shown that accelerated myelinogenesis is connected to a precocious appearance of behavioural reflexes. Thus, the use of particular lipids in human nutrition must be carefully screened for possible effects on brain development.
© 2000 S. Karger AG, Basel
Neurochemistry Section, Laboratory of Metabolism and Pathological Biochemistry
Istituto Superiore di Sanità, V.le Regina Elena
I–299-00161 Rome (Italy)
Tel. +39 06 49902574, E-Mail firstname.lastname@example.org
Received: Received: November 11, 1999
Accepted: June 30, 2000
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 4, Number of References : 46
Vol. 22, No. 5-6, Year 2000 (Cover Date: September-December (Released December 2000))
Journal Editor: A.T. Campagnoni, Los Angeles, Calif.
ISSN: 0378–5866 (print), 1421–9859 (Online)
For additional information: http://www.karger.com/journals/dne