Diet, Lipids and Brain DevelopmentSalvati S. · Attorri L. · Avellino C. · Di Biase A. · Sanchez M.
aNeurochemistry Section, Laboratory of Metabolism and Pathological Biochemistry, bLaboratory of Cell Biology, Istituto Superiore di Sanità, Rome, Italy
Brain development is a sequential anatomical process characterised by specific well-defined stages of growth and maturation. One of the fundamental and necessary events in the normal development of the central nervous system in vertebrates is the formation of a myelin sheath. It is becoming more evident that this process is influenced by dietary lipids. A number of findings have indicated that the administration of a diet deficient in essential fatty acids during development causes hypomyelination in the rat brain. Our studies have shown that lipids can also play a role in accelerating myelinogenesis in the brain of rats whose mothers had been fed, during pregnancy and lactation, a lipid fraction extracted from yeast grown on n-alkanes. Further studies have shown that accelerated myelinogenesis is connected to a precocious appearance of behavioural reflexes. Thus, the use of particular lipids in human nutrition must be carefully screened for possible effects on brain development.
Neurochemistry Section, Laboratory of Metabolism and Pathological Biochemistry
Istituto Superiore di Sanità, V.le Regina Elena
I–299-00161 Rome (Italy)
Tel. +39 06 49902574, E-Mail email@example.com
Received: Received: November 11, 1999
Accepted: June 30, 2000
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 4, Number of References : 46
Vol. 22, No. 5-6, Year 2000 (Cover Date: September-December (Released December 2000))
Journal Editor: A.T. Campagnoni, Los Angeles, Calif.
ISSN: 0378–5866 (print), 1421–9859 (Online)
For additional information: http://www.karger.com/journals/dne