Cover

Advances in the Management of Testosterone Deficiency

Editor(s): Jones T.H. (Barnsley/Sheffield) 
Table of Contents
Vol. 37, No. , 2009
Section title: Paper
Jones, T.H. (Barnsley/Sheffield) (eds): Advances in the Management of Testosterone Deficiency. Front Horm Res. Basel, Karger, 2009, vol 37, pp 108-122
(DOI:10.1159/000176048)

Erectile Dysfunction and Testosterone Deficiency

Blute M. · Hakimian P. · Kashanian J. · Shteynshluyger A. · Lee M. · Shabsigh R.
Division of Urology, Maimonides Medical Center, Brooklyn, N.Y., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 11/17/2008
Cover Date: 2009

Number of Print Pages: 15
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8622-1 (Print)
eISBN: 978-3-8055-8623-8 (Online)

Abstract

A definitive role of testosterone in erectile function has been controversial; however, recent evidence is becoming available which substantiates a key function for this hormone. Testosterone deficiency is associated with a decline in erectile function and testosterone levels are inversely correlated with increasing severity of erectile dysfunction. Erectile dysfunction can be caused by multifactorial pathologies. In particular, erectile dysfunction may be the first symptom of cardiovascular disease. Animal studies have demonstrated that castration causes vascular smooth muscle cell atrophy, venous leakage, adipocytes in the subtunical space, loss of elastic fibers and increase in collagen deposition. Testosterone increases the expression of nitric oxide synthase and phosphodiesterase type 5, both principal enzymes involved in the erectile process. Testosterone replacement alone in hypogonadal men can restore erectile function. A significant proportion of men who fail to respond to a PDE5 inhibitor are testosterone deficient. Testosterone replacement therapy can convert over half of these men into phosphodiesterase type 5 responders. It is now recommended that testosterone levels should be assessed in all patients with erectile dysfunction.


  

Publication Details

Book Serie: Frontiers of Hormone Research, Vol. 37, Year 2009

Editor(s): Grossman, A.B. (London)
ISSN: 0301-3073 (Print), eISSN: 1662-3762 (Online)

For additional information:
http://content.karger.com/ProdukteDB/produkte.asp?issn=0301-3073

Book Title: Advances in the Management of Testosterone Deficiency

Editor(s): Jones, T.H. (Barnsley/Sheffield)

For additional information:
http://content.karger.com/ProdukteDB/produkte.asp?issn=0301-3073&volume=37


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 11/17/2008
Cover Date: 2009

Number of Print Pages: 15
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8622-1 (Print)
eISBN: 978-3-8055-8623-8 (Online)


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.