Cover

Advances in the Management of Testosterone Deficiency

Editor(s): Jones T.H. (Barnsley/Sheffield) 
Table of Contents
Vol. 37, No. , 2009
Section title: Paper
Jones, T.H. (Barnsley/Sheffield) (eds): Advances in the Management of Testosterone Deficiency. Front Horm Res. Basel, Karger, 2009, vol 37, pp 133-149
(DOI:10.1159/000176050)

Frailty and Muscle Function: Role for Testosterone?

Srinivas-Shankar U. · Wu F.
Department of Endocrinology, University of Manchester, Manchester Royal Infirmary, Manchester, UK

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 11/17/2008
Cover Date: 2009

Number of Print Pages: 17
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8622-1 (Print)
eISBN: 978-3-8055-8623-8 (Online)

Abstract

Frailty is a clinical syndrome characterised by reduced physiologic reserve affecting multiple organ systems and is associated with increased risk of falls, fractures, hospitalisation and death. The impact of agerelated physical frailty on well-being and health in older men and the potential for prevention and treatment are beginning to be explored. Frailty is multifactorial with aging, comorbidity, sarcopenia, and endocrine immune dysfunction contributing to the condition. Falling testosterone levels with advancing age are associated with muscle loss (sarcopenia) and strength. Among the various therapeutic options being considered, testosterone supplementation offers promise due to its anabolic effects on muscle. In this review, we discuss the syndrome of frailty, its relationship with low testosterone and the effects of testosterone supplementation in healthy and unhealthy/frail older men on muscle mass, strength and physical performance.


  

Publication Details

Book Serie: Frontiers of Hormone Research, Vol. 37, Year 2009

Editor(s): Grossman, A.B. (London)
ISSN: 0301-3073 (Print), eISSN: 1662-3762 (Online)

For additional information:
http://content.karger.com/ProdukteDB/produkte.asp?issn=0301-3073

Book Title: Advances in the Management of Testosterone Deficiency

Editor(s): Jones, T.H. (Barnsley/Sheffield)

For additional information:
http://content.karger.com/ProdukteDB/produkte.asp?issn=0301-3073&volume=37


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 11/17/2008
Cover Date: 2009

Number of Print Pages: 17
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8622-1 (Print)
eISBN: 978-3-8055-8623-8 (Online)


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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