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Table of Contents
Vol. 85, No. 1, 1994
Issue release date: 1994
Section title: Clinical Pharmacology
Cardiology 1994;85:36–46
(DOI:10.1159/000176644)

Amlodipine versus Ramipril in the Treatment of Mild to Moderate Hypertension: Evaluation by 24-Hour Ambulatory Blood Pressure Monitoring

Perticone F. · Pugliese F. · Ceravolo R. · Mattioli P.
Department of Experimental and Clinical Medicine, University of Reggio Calabria, Catanzaro, Italy

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Article / Publication Details

First-Page Preview
Abstract of Clinical Pharmacology

Received: 8/10/1993
Accepted: 1/5/1994
Published online: 11/18/2008
Issue release date: 1994

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD

Abstract

This study was designed to compare the efficacy and tolerability of amlodipine (AML) and ramipril (RAM) administered once a day in patients affected by mild to moderate primary systemic hypertension. Twenty outpatients, 12 men and 8 women (age range 35-64 years), were enrolled. The patients received single-blind placebo for 2 weeks and thereafter in a double-blind, randomized crossover sequence AML (10 mg) and RAM (5 mg), both for 4 weeks. At the end of each period, the patients underwent 24-hour noninvasive blood pressure monitoring with readings taken every 10 min during daytime (from 07.00 to 23.00 h) and 20 min during nighttime (from 23.00 to 07.00 h). Both AML and RAM induced a highly significant (p < 0.0001) decrease in blood pressure from 162/103 ± 7/3 to 132/82 ± 6/6 and 135/83 ± 6/5 mm Hg, respectively. The mean blood pressure decreased from 122 ± 5 to 99 ± 6 (AML; p < 0.0001) and 100 ± 5 mm Hg (RAM; p < 0.0001). No significant differences in heart rate were noted during drug administrations. Treatment did not have to be discontinued in any patient because of adverse reactions. In conclusion, both AML and RAM reduced the blood pressure markedly, even if AML proved to be significantly more effective than RAM.

© 1994 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Clinical Pharmacology

Received: 8/10/1993
Accepted: 1/5/1994
Published online: 11/18/2008
Issue release date: 1994

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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