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Table of Contents
Vol. 34, No. 3, 1990
Issue release date: 1990
Section title: Original Paper
Ann Nutr Metab 1990;34:133–142
(DOI:10.1159/000177579)

Effects of a Short-Term (4 Weeks) Protein-Sparing Modified Fast on Plasma Lipids and Lipoproteins in Obese Women

Vermeulen A.
Department of Endocrinology, University Hospital, Gent, Belgium

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 08, 1989
Accepted: November 10, 1989
Published online: November 19, 2008
Issue release date: 1990

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM

Abstract

The aim of this study was to evaluate the effects of a short-term (4 weeks) protein-sparing modified fast (PSMF) diet of 400 cal on plasma lipids and lipoproteins in a group (n = 51) of pre- and postmenopausal women with moderately severe obesity (body mass index > 30) as well as the eventual relations of plasma lipids to the type of fat distribution. Women with android-type obesity had higher plasma cholesterol, low-density lipoprotein cholesterol (LDL-C), apoprotein B (apoB) and glucose levels and lower high-density lipoprotein cholesterol (HDL-C) levels and HDL-C/LDL-C ratio than women with gynoid-type obesity. Besides waist-hip ratio (WHR), also age was an important determinant of HDL-C and HDL-C/LDL-C. PSMF for 4 weeks caused a 20% decrease in plasma cholesterol, LDL-C and apoB levels but also a decrease of HDL-C, apoAl and apoA2. Nevertheless the HDL-C/LDL-C ratio increased, and, overall, PSMF resulted in less atherogenic profile of plasma lipids. Weight loss was independent of WHR but somewhat higher in premenopausal women (mean 10 kg) than in postmenopausal women (mean 8 kg), suggesting a more important energy deficit in pre- than in postmenopausal women. No correlation was observed between the importance of weight loss and the changes in plasma lipid levels: this indicates that the normalization of plasma lipids is the consequence of the diet itself and not secondary to weight loss.

© 1990 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 08, 1989
Accepted: November 10, 1989
Published online: November 19, 2008
Issue release date: 1990

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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