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Vol. 36, No. 3, 1992
Issue release date: 1992
Section title: Original Paper
Ann Nutr Metab 1992;36:157–161
(DOI:10.1159/000177711)

Effet de l'acide folique et de l'acide folinique sur l'absorption du zinc

Effect of Folic and Folinic Acids on Zinc Intestinal Absorption

Arnaud J.a · Favier A.a · Herrmann M.A.b · Pilorget J.J.b
aLaboratoire de Biochimie C, CHRUG, Grenoble, bLaboratories Lederle, Rungis, France

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 11/20/2008
Issue release date: 1992

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM

Abstract

We have investigated the effect of folic and folinic acids on intestinal zinc absorption in humans, using zinc tolerance tests. Zinc (30 mg) as the gluconate was given by mouth to 10 healthy subjects, alone (1), with 200 mg of folic acid (2) or with 200 mg of folinic acid (3). The zinc/folate molar ratio was 1:1. These three oral loading doses were given after overnight fasting to each of the 10 subjects, at weekly intervals. Serum zinc was measured at 0, 1 2, 3,6, 12 and 24 h. Zinc was also determined in urine collected for a 6-hour period following the ingestion of oral loading dose. The results do not indicated any inhibition of zinc absorption and urinary zinc excretion by folates. The areas under the curves varied from 48.2 ± 20.0 μmol/6h(l)to 57.0 ± 10.3 μmol/6 h (3), peak zinc concentration from 28.8 ± 7.3 μmol/l (1) to 32.1 ± 4.1 μmol/l (3), half-life from 3.12 ± 1.12 h (3) to 3.42 ± 1.48 h (1), elimination rate constant from 0.22 ± 0.08 (1) to 0.24 ± 0.07 (3), mean urinary zinc excretion from 58.1 μmol/6h (2) to 98.7 μmol/6 h (1) and mean zinc clearance from 1.15 1/h (3) to 3.26 1/h (1). All these indices were not statistically significantly different among the three different loading doses.

© 1992 S. Karger AG, Basel


  

Article Information

Number of Print Pages : 5

  

Publication Details

Annals of Nutrition and Metabolism (Journal of Nutrition, Metabolic Diseases and Dietetics)

Vol. 36, No. 3, Year 1992 (Cover Date: 1992)

Journal Editor: Elmadfa I. (Vienna)
ISSN: 0250–6807 (Print), eISSN: 1421–9697 (Online)

For additional information: http://www.karger.com/ANM


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 11/20/2008
Issue release date: 1992

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


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