Nasal Saline Irrigation Facilitates Control of Allergic Rhinitis by Topical Steroid in ChildrenLi H. · Sha Q. · Zuo K. · Jiang H. · Cheng L. · Shi J. · Xu G.
aDepartment of Otolaryngology, First Affiliated Hospital of Nanjing Medical University, Nanjing, bAllergy and Immunology Research Center and Department of Immunology, Anhui Medical University, Hefei, and cOtorhinolaryngology Hospital, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China
Objective: This study was designed to determine whether nasal saline irrigation improved the symptoms and signs of allergic rhinitis (AR) and whether nasal saline irrigation could be used as a complementary management of AR in children while less steroids were used. Method: 26 children with AR were divided into three groups and were given nasal saline irrigation and/or topical steroid. Symptoms and signs of AR and mucociliary clearance (MCC) were evaluated, and concentration of soluble intercellular adhesion molecule (sICAM)-1 in nasal secretion was detected. Results: In AR children treated with nasal irrigation and tapered topical steroid at week 8 and week 12, a significant improvement in symptoms and signs was observed, and a significant decrease in the mean values of MCC and the mean concentrations of sICAM-1 in nasal secretions was also detected. Conclusion: Nasal saline irrigation can be viewed as a good adjunctive treatment option for AR. It permitted the use of less topical steroids for controlling AR in children, which will contribute to fewer side effects and less economic burden.
Geng Xu, MD
First Affiliated Hospital of Sun Yat-sen University
Zhongshan Street 58, Guangzhou 510080 (PR China)
Tel. +86 20 8733 3733, Fax +86 20 8733 3108, E-Mail firstname.lastname@example.org
Huabin Li and Quan Sha contributed equally to this study.
Received: March 5, 2008
Accepted after revision: June 26, 2008
Published online: December 1, 2008
Number of Print Pages : 6
Number of Figures : 4, Number of Tables : 1, Number of References : 25
ORL (Journal for Oto-Rhino-Laryngology, Head and Neck Surgery)
Vol. 71, No. 1, Year 2009 (Cover Date: December 2008)
Journal Editor: O'Malley Jr. B.W. (Philadelphia, Pa.)
ISSN: 0301–1569 (Print), eISSN: 1423–0275 (Online)
For additional information: http://www.karger.com/ORL