The Organ-Maintained Human Sebaceous GlandGuy R. · Kealey T.
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK
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In the absence of epidermal growth factor (EGF) and phenol red in the maintenance medium, human sebaceous glands apparently retain in vivo rates of cell division and lipogenesis over 7 days and also retain in situ morphology. This is reversible on the re-addition of 10 ng/ml EGF and 10 mg/ml phenol red. The addition of 600 pM 17β-oestradiol results in a significant fall in the rate of lipogenesis over 7 days’ maintenance, without affecting the rate of cell division. This effect is apparently due to abnormal differentiation of newly formed sebocytes. Neither 1 nM testosterone nor 1 nM dihydrotestosterone has any effect on rates of cell division or lipogenesis over 7 days. 1 μM 13-cis-retinoic acid causes a significant reduction in the rate of lipogenesis over 7 days.
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