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Table of Contents
Vol. 5, No. 1, 1974
Issue release date: 1974
Section title: Paper
Horm Res 1974;5:21–28
(DOI:10.1159/000178615)

Melatonin Inhibition of Insulin Secretion in the Rat and Mouse

Bailey C.J. · Atkins T.W. · Matty A.J.
Department of Biological Sciences, University of Aston in Birmingham, Birmingham

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: November 21, 2008
Issue release date: 1974

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

The effect of melatonin (100 µg/ml) on basal and glucose-induced insulin secretion was investigated using micro-dissected pancreatic islets of obese hyper-glycaemic mice and their normal lean littermates, and pieces of rat pancreas. Melatonin had no significant effect on basal insulin secretion from both normal and obese mouse islets, but significantly reduced basal insulin secretion from pieces of rat pancreas. However, glucose-induced insulin secretion was significantly inhibited by melatonin in both preparations. A constant infusion of melatonin into rats undergoing intravenous glucose tolerance tests did not alter blood sugar levels and produced only a marginal decrease in plasma insulin levels. It is suggested that melatonin may be involved in the monoaminergic regulation of insulin secretion.

© 1974 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: November 21, 2008
Issue release date: 1974

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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