Advances in tissue engineering of skin are needed for clinical applications (as in wound healing and gene therapy) for cutaneous and systemic diseases. In this paper we review the use of epidermal stem cells as a source of cells to improve tissue-engineered skin. We discuss the importance and limitations of epidermal stem cell isolation using biomarkers, in quest of a pure stem cell preparation, as well as the culture conditions necessary to maintain this purity as required for a qualitatively superior and long-lasting engineered skin. Finally, we review the advantages of using additional multipotent stem cell sources to functionally and cosmetically optimize the engineered tissue.
Prof. Ruby Ghadially, MD
Dermatology Research, University of California, Department of Dermatology
Veteran’s Affairs Medical Center
4150 Clement Street MC190, San Francisco, CA 94121 (USA)
Tel. +1 415 221 4810, ext. 3373, Fax +1 415 750 6959, E-Mail firstname.lastname@example.org
Published online: February 4, 2009
Number of Print Pages : 8
Number of Figures : 0, Number of Tables : 0, Number of References : 74
Skin Pharmacology and Physiology (Journal of Pharmacological and Biophysical Research)
Vol. 22, No. 2, Year 2009 (Cover Date: February 2009)
Journal Editor: Lademann J. (Berlin)
ISSN: 1660-5527 (Print), eISSN: 1660-5535 (Online)
For additional information: http://www.karger.com/SPP
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