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Table of Contents
Vol. 196, No. 4, 1998
Issue release date: 1998
Section title: Report
Dermatology 1998;196:474–477
(DOI:10.1159/000017954)

Ketoconazole Shampoo: Effect of Long-Term Use in Androgenic Alopecia

Piérard-Franchimont C.a · De Doncker P.b · Cauwenbergh G.c · Piérard G.E.a
aDepartment of Dermatopathology, University of Liège, and bJanssen Research Foundation, Beerse, Belgium; cJohnson and Johnson Research and Development, Skillman, N.J., USA

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Article / Publication Details

First-Page Preview
Abstract of Report

Published online: June 26, 1998
Issue release date: 1998

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Background: The pathogenesis of androgenic alopecia is not fully understood. A microbial-driven inflammatory reaction abutting on the hair follicles might participate in the hair status anomaly. Objective: The aim of our study was to determine if ketoconazole (KCZ) which is active against the scalp microflora and shows some intrinsic anti-inflammatory activity might improve alopecia. Method: The effect of 2% KCZ shampoo was compared to that of an unmedicated shampoo used in combination with or without 2% minoxidil therapy. Results: Hair density and size and proportion of anagen follicles were improved almost similarly by both KCZ and minoxidil regimens. The sebum casual level appeared to be decreased by KCZ. Conclusion: Comparative data suggest that there may be a significant action of KCZ upon the course of androgenic alopecia and that Malassezia spp. may play a role in the inflammatory reaction. The clinical significance of the results awaits further controlled study in a larger group of subjects.


Article / Publication Details

First-Page Preview
Abstract of Report

Published online: June 26, 1998
Issue release date: 1998

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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