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Table of Contents
Vol. 16, No. 1, 2009
Issue release date: January 2009
Section title: Original Paper
Neuroimmunomodulation 2009;16:19–27
(DOI:10.1159/000179663)

Pharmacological Manipulation of Immune-Induced Food Aversion in Rats

Zarzana E.C. · Basso A.S. · Costa-Pinto F.A. · Palermo-Neto J.
Laboratory of Pharmacology and Toxicology, Department of Pathology, School of Veterinary Medicine, University of São Paulo, São Paulo, Brazil

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 22, 2008
Accepted: June 06, 2008
Published online: December 15, 2008
Issue release date: January 2009

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 2

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM

Abstract

Background: Mice allergic to ovalbumin (OVA) avoid drinking a solution containing this antigen. This was interpreted as related to IgE-dependent mast cell degranulation and sensory C fiber activation. Methods: We employed pharmacological manipulation to further investigate the mediators involved in immune-induced food aversion. Results: While nonimmunized rats preferred a sweetened OVA solution, immunized rats avoided it. We also employed a paradigm in which rats are conditioned to drink water for two 10-min sessions a day. Tolerant rats presented lower IgE titers, and this manipulation abrogated food aversion. Dexamethasone (1.0 mg/kg) prevented the aversion of OVA-immunized rats to the antigen-containing solution. Combined blockade of H1 and 5-hydroxytryptamine (5-HT)2 receptors by promethazine (3.0 mg/kg) plus methysergide (5.0 mg/kg) was unable to alter food aversion. Blockade of 5-HT3 receptors by ondansetron (1.0 mg/kg) caused a twofold increase in the ingestion of the sweetened OVA solution by immunized rats, suggesting the involvement of 5-HT3 receptors in food aversion. Finally, we showed that dexamethasone or promethazine plus methysergide, but not ondansetron, effectively prevented the IgE-dependent mast-cell-degranulation-induced increase in vascular permeability in rats. Conclusion: We suggest that regardless of whether or not they cause edema, IgE-mediated mast cell degranulation and consequent 5-HT3 signaling are involved in the process that triggers avoidance to the source of the allergen in allergic rats.

© 2008 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 22, 2008
Accepted: June 06, 2008
Published online: December 15, 2008
Issue release date: January 2009

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 2

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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