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Table of Contents
Vol. 21, No. 3, 1985
Issue release date: 1985
Section title: Paper
Horm Res 1985;21:137–144
(DOI:10.1159/000180038)

Prolactin and Thyrotropin Response to Thyrotropin-Releasing Hormone in Premenopausal Women with Fibrocystic Disease of the Breast

Dogliotti L.a · Faggiuolo R.a · Ferusso A.a · Orlandi F.a · Sandrucci S.b · Tibo A.a · Angeli A.a
aIstituto di Medicina Interna, Cattedra di Patologica Medica D, and bClinica Chirurgica A, Università degli Studi, Torino, Italia

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 4/12/1984
Accepted: 9/14/1984
Published online: 11/26/2008
Issue release date: 1985

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

Plasma PRL, TSH, total and free T4, total and free T3, and 17β-estradiol were evaluated in 29 premenopausal women with well-documented fibrocystic disease of the breast and in 29 healthy matched controls. Plasma PRL and TSH dynamics after acute TRH injection (200 µg i.v.) were also determined. All hormonal measurements were performed in the follicular phase of the menstrual cycle. Neither patients nor controls showed any thyroid function impairment. Basal plasma levels of the examined hormones were in the normal range in both groups. When considering data pertinent to PRL and TSH secretory patterns after TRH stimulation, no difference was recorded between patients and controls for TSH secretion, evaluated in terms of maximum peak, net (Δ) and percent (Δ%) increase above the baseline level and integrated area of response. On the contrary, the response of PRL was significantly higher in patients than controls (maximum peak at 20min, mean ± SE, 119.9 ± 14.1 vs. 60.8 ± 5.5 ng/ml, p < 0.001; integrated area of response, 5,725 ± 908 vs. 3,243 ± 266 ng/ml/120 min, p < 0.01). The results are compatible with the view that, in most patients with fibrocystic disease of the breast, there are abnormalities in the control of PRL secretion, which lead to enhanced release of the hormone after stimulation. In such cases the control of TSH appears to be operating normally.

© 1985 S. Karger AG, Basel


  

Author Contacts

Luigi Dogliotti, MD, Patologia Medica D, Università di Torino, Strada San Vito, 34, I-10133 Torino (Italy)

  

Article Information

Received: April 12, 1984
Accepted after revision: September 14, 1984
Published online: November 26, 2008
Number of Print Pages : 8

  

Publication Details

Hormone Research (From Developmental Endocrinology to Clinical Research)

Vol. 21, No. 3, Year 1985 (Cover Date: 1985)

Journal Editor: Czernichow P. (Paris)
ISSN: 0301–0163 (Print), eISSN: 1423–0046 (Online)

For additional information: http://www.karger.com/HRE


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 4/12/1984
Accepted: 9/14/1984
Published online: 11/26/2008
Issue release date: 1985

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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