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Vol. 10, No. 1, 1973
Issue release date: 1973
Nephron 1973;10:37–56

Comparison of Azathioprine, Prednisone, and Heparin Alone or Combined in Treating Lupus nephritis

Cade R. · Spooner G. · Schlein E. · Pickering M. · de Quesada A. · Holcomb A. · Juncos L. · Richard G. · Shires D. · Levin D. · Hackett R. · Free J. · Hunt R. · Fregly M.
Departments of Medicine, Pediatrics, Pathology and Physiology, University of Florida Medical College, Gainesville, Fla.


50 patients with proliferative glomerulonephritis due to lupus erythematosus were assigned in order of their chronologic appearance at the hospital alternately to treatment with either daily high dose prednisone, azathioprine, prednisone and azathioprine combined, or combined azathioprine and heparin. Prednisone alone was ineffective both from a standpoint of maintaining kidney function or from preserving a state of well being. Only 2 of 15 patients treated with prednisone are doing well with an average survival for the group of 19 months. Azathioprine, alone, appeared very effective with 9 of 13 patients alive and doing well with an average survival of 38 months. Combinations of either azathioprine and prednisone or azathioprine and heparin were most successful, only 2 of 13 in each group died of renal failure. Complications of prednisone administra’ion were high both when prednisone was given alone or in combination with azathioprine.

 goto top of outline Author Contacts

Authors’ addresses: Robert Cade, Edward Schlein, George Richard, Raymond Hackett, Raymond Hunt, and Melvin Fregley, University of Florida, Medical School, Gainesville, FL 32601; George Spooner, University Medical Center, Jacksonville, Fla.; Dana Shires and Alex deQuesada, University of Indiana, Medical School, Indianapolis, Ind.; Alan Holcomb, Orange Memorial Hospital, Orlando, Fla.; Daniel Levin, Poly Clinic, Harrisburg, Pa.; Michael Pickering, Watson Clinic, Lakeland, Fla.; and Harry J. Free, Morton Plant Hospital, Clearwater, Fla. (USA)

 goto top of outline Article Information

Number of Print Pages : 20

 goto top of outline Publication Details


Vol. 10, No. 1, Year 1973 (Cover Date: 1973)

Journal Editor: Fine L.G. (Los Angeles, Calif.)
ISSN: 0028–2766 (Print), eISSN: 1423–0186 (Online)

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