Imprinting of Male Sex Tissues by Neonatal Endogenous Androgens in Mice
Molecular Alterations following Exposure to Cyproterone AcetateJean-Faucher C. · Berger M. · Gallon C. · de Turckheim M. · Veyssière G. · Jean C.
Physiologie Comparée et Endocrinologie, CNRS LA 360, Université Clermont II, Complexe Scientifique des Cézeaux, Aubière, France
This study was conducted to evaluate the growth and biochemical responsiveness of the epididymis, vas deferens and seminal vesicles of adult mice exposed to cyproterone acetate during the first 10 days of life. Results indicate that the weight and protein content of sex accessory organs were significantly depressed, testosterone and dihydrotestosterone concentrations were unaffected or increased, the number of cytosolic androgen-binding sites was slightly or significantly reduced. The efficiency of exogenous testosterone in promoting growth and protein synthesis in target organs of castrated adult males was significantly lowered by neonatal cyproterone acetate treatment. It is concluded that a deficient androgenic stimulation during neonatal life induces a limited response of sex target organs to endogenous or exogenous androgens in adulthood.
© 1986 S. Karger AG, Basel
C. Jean-Faucher, MD, Physiologie Comparée et Endocrinologie, CNRS LA 360, Université Clermont II, Complexe Scientifique des Cézeaux, B.P. 45, F-63170 Aubière (France)
Received: October 10, 1985
Accepted after revision: December 19, 1985
Published online: November 28, 2008
Number of Print Pages : 8
Hormone Research (From Developmental Endocrinology to Clinical Research)
Vol. 24, No. 1, Year 1986 (Cover Date: 1986)
Journal Editor: Czernichow P. (Paris)
ISSN: 0301–0163 (Print), eISSN: 1423–0046 (Online)
For additional information: http://www.karger.com/HRE