Login to MyKarger

New to MyKarger? Click here to sign up.

Login with Facebook

Forgot Password? Reset your password

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login (Shibboleth)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Table of Contents
Vol. 67, No. 3, 2009
Issue release date: February 2009
Section title: Original Paper
Free Access
Hum Hered 2009;67:193–205

Analysis of 30 Genes (355 SNPS) Related to Energy Homeostasis for Association with Adiposity in European-American and Yup’ik Eskimo Populations

Chung W.K.a, b · Patki A.c · Matsuoka N.a, b · Boyer B.B.d · Liu N.c · Musani S.K.c · Goropashnaya A.V.d · Tan P.L.e · Katsanis N.e · Johnson S.B.a · Gregersen P.K.f · Allison D.B.c · Leibel R.L.a, b · Tiwari H.K.c
aColumbia University Medical Center, New York, NY, bNaomi Berrie Diabetes Center, New York, NY, cUniversity of Alabama at Birmingham, Birmingham, Ala., dUniversity of Alaska Fairbanks, Fairbanks, Alaska, eJohns Hopkins University, Baltimore, Md., and fFeinstein Institute for Medical Research, Manhasset, NY, USA
email Corresponding Author

Wendy K. Chung

Columbia University Medical Center

1150 St. Nicholas Avenue, Room 620

New York, NY 10032 (USA)

Tel. +1 212 851 5313, Fax +1 212 851 5306, E-Mail wkc15@columbia.edu

Do you have an account?

Login Information

Contact Information

I have read the Karger Terms and Conditions and agree.


Objective: Human adiposity is highly heritable, but few of the genes that predispose to obesity in most humans are known. We tested candidate genes in pathways related to food intake and energy expenditure for association with measures of adiposity. Methods: We studied 355 genetic variants in 30 candidate genes in 7 molecular pathways related to obesity in two groups of adult subjects: 1,982 unrelated European Americans living in the New York metropolitan area drawn from the extremes of their body mass index (BMI) distribution and 593 related Yup’ik Eskimos living in rural Alaska characterized for BMI, body composition, waist circumference, and skin fold thicknesses. Data were analyzed by using a mixed model in conjunction with a false discovery rate (FDR) procedure to correct for multiple testing. Results: After correcting for multiple testing, two single nucleotide polymorphisms (SNPs) in Ghrelin (GHRL) (rs35682 and rs35683) were associated with BMI in the New York European Americans. This association was not replicated in the Yup’ik participants. There was no evidence for gene × gene interactions among genes within the same molecular pathway after adjusting for multiple testing via FDR control procedure. Conclusion: Genetic variation in GHRL may have a modest impact on BMI in European Americans.

© 2008 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 19, 2008
Accepted: July 10, 2008
Published online: December 15, 2008
Issue release date: February 2009

Number of Print Pages: 13
Number of Figures: 4
Number of Tables: 8

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

For additional information: http://www.karger.com/HHE

Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.