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Table of Contents
Vol. 9, No. 5, 2009
Issue release date: November 2009
Section title: Original Paper
Pancreatology 2009;9:670–676
(DOI:10.1159/000181179)

A Preoperative Prognostic Score for Resected Pancreatic and Periampullary Neuroendocrine Tumours

Sakka N.a · Smith R.A.a · Whelan P.a · Ghaneh P.a · Sutton R.a · Raraty M.a · Campbell F.b · Neoptolemos J.P.a
aDivision of Surgery and Oncology, School of Cancer Studies, University of Liverpool, and bDepartment of Pathology, Royal Liverpool University Hospital, Liverpool, UK

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 08, 2008
Accepted: October 29, 2008
Published online: August 14, 2009
Issue release date: November 2009

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 3

ISSN: 1424-3903 (Print)
eISSN: 1424-3911 (Online)

For additional information: http://www.karger.com/PAN

Abstract

Background/Aims: To identify potential preoperative prognostic factors in resected pancreatic and periampullary neuroendocrine tumours. Methods: Clinico-pathological data for 54 consecutive patients with pancreatic or periampullary neuroendocrine tumours referred to our institution over a 10-year period were identified from a prospective database. Results: 34 patients underwent pancreatic resection (12 males, 22 females; median age 54 (IQR 44–71) years). There was a single 30-day mortality (3%). Nodal status (log rank, p = 0.652), microscopic resection margin involvement (p = 0.549) and tumour size (p = 0.122) failed to exhibit any prognostic value. Only the presence of malignant tumour characteristics was associated with poorer overall survival (p = 0.008). Analysis of preoperative parameters showed that age >60 years (p = 0.056), platelet-lymphocyte ratio >300 (p = 0.008), alkaline phosphatase levels >125 U/l (p = 0.042) and alanine aminotransferase >35 U/l (p = 0.016) were adverse prognostic factors. A risk stratification score was generated where each adverse preoperative parameter was allocated a score of 1. A cumulative score of ≤1 was defined as low risk, while a score of ≥2 was defined as high risk. Median overall survival in the high-risk group was 10.4 months, while the median survival in the low-risk group was >60 months (p < 0.001). Conclusion: Significant prognostic information can be gained from routine preoperative biochemistry and haematology results in resected pancreatic and periampullary neuroendocrine tumours. These findings merit further evaluation in a larger patient cohort.

© 2009 S. Karger AG, Basel and IAP


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 08, 2008
Accepted: October 29, 2008
Published online: August 14, 2009
Issue release date: November 2009

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 3

ISSN: 1424-3903 (Print)
eISSN: 1424-3911 (Online)

For additional information: http://www.karger.com/PAN


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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